摘要
目的 :探讨乳腺癌患者血清血管内皮生长因子 (VEGF)的变化及其临床意义。方法 :用 EL ISA法检测 36例乳腺癌患者、 2 2例乳腺纤维腺瘤及乳腺囊性增生患者和 35例正常健康女性血清 VEGF含量 ,分析 VEGF与临床指标的关系。结果 :VEGF水平乳腺癌组 [(14 5 .8± 13.6 ) ng· L- 1 ]与良性病变组 [(80 .4 7± 3.5 8) ng· L- 1 ]和正常对照组 [(5 8.38± 7.0 4 ) ng· L- 1 ]比较差异有显著性 (P<0 .0 5 ) ,VEGF水平有淋巴结转移者 [(188.4 0±19.80 ) ng· L- 1 ]明显高于无淋巴结转移者 [(94 .0 2± 12 .0 4 ) ng· L- 1 ](P<0 .0 1)。结论 :乳腺癌患者血清中VEGF含量可能成为鉴别乳腺良恶性病变的辅助指标之一 ,有助于判断有无淋巴结转移及预后。
Objective To study the changes of serum vascular endothelial growth factor (VEGF) in patients with breast cancer and its significance. Methods The preoperative fasting serum VEGF levels were determined in 36 patients with breast cancer, 22 patients with breast fibroadenoma and breast cystic hyperplasia, and 35 healthy female controls by using ELISA. The relationships between VEGF and clinical indexes were analyzed. Results The serum VEGF level (ng·L -1) in breast cancer group (145.8±13.6) was significantly higher than those in benign breast disease group (80.47±3.58) and control group (58.38±7.04) (P<0.05). The VEGF level (ng·L -1) in patients with lymph node metastasis (188.40±19.80) was higher than that in patients without lymph node metastasis (94.02±12.04)(P<0.01). Conclusion The serum VEGF level has certain value to make differential diagnosis between malignant and benign breast diseases and predict the possibilities of prognosis and lymph node metastasis.
出处
《吉林大学学报（医学版）》
CAS
CSCD
北大核心
2005年第1期133-135,共3页
Journal of Jilin University：Medicine Edition
基金
长春市科委资助课题 (0 4 - 0 7SF0 2 0 )
关键词
乳腺肿瘤/血液
血管内皮生长因子
内皮
血管
肿瘤转移
预后
breast neoplasms/blood
vascular endothelial growth factor
endothelium, vascular
neoplasm metastasis
prognosis
