摘要
探讨不同产地口蘑多糖对亚急性衰老模型小鼠的抗衰老作用.用D-半乳糖制备衰老小鼠模型,随机分为正常组、模型组、内蒙古产口蘑多糖组(低、中、高剂量)、张家口产口蘑多糖组(低、中、高剂量)及阳性对照组.连续灌胃给药30 d后,Morris水迷宫检测小鼠学习能力,观察其对血清、肝脏和脑组织中超氧化物歧化酶(SOD)、过氧化氢酶(CAT)的活性及丙二醛(MDA)含量.结果显示,与模型组比较,内蒙古产口蘑和张家口产口蘑多糖各剂量组小鼠的学习能力均有所提高,口蘑多糖能不同程度增加血清、肝脏和脑组织SOD、CAT的活力,显著降低MDA含量.而相同剂量的内蒙古产口蘑多糖和张家口产口蘑多糖组间未见显著性差异.
We discussed the anti-aging effect of polysaccharides in mushroom from different places on subacute aging model mice. We prepared aging mice models by injecting D-galactose,and randomly grouped the models to a normal group,a model group, Inner Mongolia mushroom polysaccharide groups（low-,medium- and high-dose）,Zhangjiakou mushroom polysaccharide groups（low-,medium- and high-dose）,and a positive control group. We determined the learning ability of the mice by Morris water maze test after consecutive intragastric administration for 30 days,and studied the effects of mushroom polysaccharides on SOD（superoxide dismutase）activity,CAT（catalase） activity and MDA（malondialdehyde） content in serum,liver and brain tissue of mice.The results showed that the learning ability of mice of the Inner Mongolia mushroom polysaccharide groups and the Zhangjiakou mushroom polysaccharide groups was improved（P〈0.05）;and mushroom polysaccharides could enhance the activities of SOD and CAT in serum,liver and brain tissue,and remarkably reduce the MDA content. The indexes of mice of the Inner Mongolia mushroom polysaccharide groups and the Zhangjiakou mushroom polysaccharide groups of the same dose had no obvious remarkable difference.
出处
《河南工业大学学报（自然科学版）》
CAS
北大核心
2015年第1期72-75,共4页
Journal of Henan University of Technology：Natural Science Edition
基金
张家口市科学技术研究与发展计划项目(1311017C-1)
河北省高等学校科学技术研究项目(Z2013006)
关键词
口蘑
多糖
抗衰老
mushroom
polysaccharide
anti-aging
