摘要
目的本研究旨在探讨血浆白细胞介素(IL)-23和IL-17水平与慢性阻塞性肺疾病(COPD)的关系。方法收集75例COPD患者和80例正常对照者,采用酶联免疫吸附法检测血浆IL-23和IL-17水平。经t检验比较血浆IL-23和IL-17水平在COPD组和对照组之间的差异,以及其与COPD患者病程的关系。采用Pearson相关分析法检验COPD患者中血浆IL-23与IL-17水平的相关性。结果 COPD患者中血浆IL-23和IL-17的平均水平均显著高于对照组(IL-23:751.17±155.36 vs 686.88±147.36ng/L,t=2.644,P=0.009;IL-17:1.79±0.21 vs 1.71±0.17ng/L,t=2.614,P=0.010)。与稳定期COPD患者相比较,急性加重期患者中血浆IL-23和IL-17的平均水平亦显著升高(IL-23:801.31±141.69 vs 717.75±128.74ng/L,t=2.645,P=0.010;IL-17:2.36±0.12 vs 1.41±0.16ng/L,t=27.714,P<0.001)。采用Pearson相关分析法,结果显示,COPD患者中血浆IL-23水平与IL-17水平呈正相关(r=0.349,P=0.011)。结论血浆IL-23和IL-17水平可能参与COPD的形成,并能影响疾病的病程。COPD患者中血浆IL-23水平与IL-17水平密切相关。
Objective To analyze the associations of chronic obstructive pulmonary disease （COPD） with plasma levels of interleu- kin（IL） - 23 and IL - 17. Methods A total of 75 COPD patients and 80 healthy controls were collected. Plasma levels of IL - 23 and IL - 17 were examined by enzyme - linked immunosorbent assay （ ELISA）. Comparison of average plasma levels of IL -23 and IL - 17 be- tween groups was performed by Student＇s test. Pearson correlative analysis was further conducted to evaluate the relationship between plas- ma levels of IL - 23 and IL - 17 in patients with COPD. Results The average plasma levels of IL - 23 and IL - 17 in COPD patients were significantly higher than in the controls （IL - 23 ： 751.17± 155.36 vs 686.88 ± 147.36 ng/L, t = 2. 644, P = 0. 009 ; IL - 17 ： 1.79 ± 0.21 vs 1.71± 0.17 ng/L, t = 2. 614, P = 0. 010）. Furthermore, the average plasma levels of IL - 23 and IL - 17 were signifi- cantly higher in patients with acute exacerbations of COPD than in those with COPD on stable phase （ IL - 23 ： 801.31 ± 141.69 vs 717.75± 128.74 ng/L, t =2.645, P =0.010; IL - 17：2.36 ±0.12 vs 1.41 ±0.16 ng/L, t =27.714, P =0.000）. By means of Pear- son correlative analysis, moreover, the plasma levels of IL - 23 in COPD patients were found to he positively reiated with the plasma levels of IL- 17 （r = 0. 349, P = 0. 011）. Conclusion The plasma levels of IL -23 and IL -17 may be involved in the development of COPD, and influence the course of the disease in COPD patients. Plasma levels of IL - 23 in patients with COPD was closely linked to the levels of IL - 17.
出处
《医学研究杂志》
2015年第2期123-126,共4页
Journal of Medical Research
