摘要
目的 评价预先静脉滴注（简称：预注）硫酸镁及小剂量罗库溴铵对快速顺序插管过程的影响.方法 选择84例ASA Ⅰ～Ⅱ级择期全身麻醉患者,随机分为3组：A组麻醉前预注50mg/kg硫酸镁,诱导时给予0.6mg/kg罗库溴铵;B组预注等量硫酸镁,且在诱导前预注0.06mg/kg罗库溴铵,诱导时再给予0.54mg/kg的余量;C组为对照组,每组28例.记录各组的起效时间、阻断时间、插管条件以及插管过程中的平均动脉压和心率变化.结果 起效时间：B组＜A组＜C组（P＜0.05）;A、B组阻断时间明显长于C组（P＜0.01）,且插管条件也显著优于C组（P＜0.05）.插管后即刻A、B组的平均动脉压显著低于C组（P＜0.01）.结论 预注硫酸镁和小剂量的罗库溴铵作为快速诱导插管的辅助方法,可使整个过程更加高效、平稳,值得进一步推广.
Objective To investigate the effect of magnesium sulphate pre - treatment and rocuronium priming on rapid sequence in- tubation （RSI）. Methods Eighty fowr patients with ASA Ⅰ - Ⅱ , who have undergone elective surgery under general anesthesia, were randomly assigned into three groups with 28 cases in each group. Patients in group A were administrated 50mg/kg magnesium sulphate be- fore anesthesia and 0.6mg/kg rocuronium for induction. Equivalent magnesium sulphate was given to patient in group B and 0. 06mg/kg rocuronium was administrated 3min before a further dose of 0.54mg/kg rocuronium. Group C was control group. The time from the last in- jection of rocuronium to 100% depression of the single twitch （ onset time） and return of adequate neuromuscular transmission as measured by train -of- four equal to two （duration of blockade） , tracheal intubation condition and the changes of MAP and HR during the process of intubation were measured. Results Onset time was as fllowing of group B （87.9 ± 12.7s） 〈 group A （ 102.8 ± 12.9s） 〈 group C （110.9 ± 13.8s）（ P 〈 0.05 ） ; Blockade duration in group A and B were （42.0 ± 5.6 ）s and （40.6 ± 6.0）s, which was significantly lon- ger than group C （32.6 ± 6.1 s）（P 〈 0.01 ）. Tracheal intubation condition of patients in group A and B was significantly better than group C （P 〈0.05）. Compared with group C, significant reduction in MAP and HR was observed in group A and B after intubation instantly （ 87.2 ± 7.1 mmHg and 87.7 ± 5.9mmHg vs 95.5 ± 9.1 mmHg,P 〈 0. 01 ）. Conclusion As an auxiliary method for rapid sequence intu- bation, magnesium sulphate pre - treatment and rocuronium priming can accelerate and smooth the whole process, which deserve to be further developed and popularized.
出处
《医学研究杂志》
2015年第1期110-112,共3页
Journal of Medical Research
关键词
硫酸镁
罗库溴铵
快速顺序插管
预注法
Magnesium sulphate
Rocuronium
Rapid sequence intubation
Priming principle
