摘要
探讨双脉冲多普勒技术评价2型糖尿病(DM)患者左心室舒张功能的应用价值,并分析影响DM患者左心室舒张功能的相关因素。连续纳入50例非肥胖、无高血压病史的2型DM患者和48名年龄、性别相匹配的志愿者。采用HITACHI Ascendus多普勒超声诊断仪,应用双脉冲多普勒同步取样技术测量二尖瓣口舒张期峰值流速(E峰、A峰)、减速时间(DT)、二尖瓣前瓣环舒张期峰值速度(e’峰),左心室等容舒张时间(IVRT),计算E/A、E/e’比值、Tei指数及E峰与e’峰的起始时间差(TE-e’)。随机选取20例受试者进行IVRT、TE-e’重复性分析。结果显示两组左心室舒张功能参数比较:DM组E/A比值、e’峰降低,E/e’比值、Tei指数升高,DT、IVRT、TE-e’延长,差异有统计学意义(P<0.05);线性回归显示TE-e’与IVRT呈正相关(r=0.415,P=0.000);DM患者病程与TE-e’呈正相关(Beta=0.295,P=0.020),糖化血红蛋白(HbA1C)水平与TE-e’呈正相关(Beta=0.399,P=0.010);重复性分析显示IVRT、TE-e’测量组内和组间重复性均较好。双脉冲多普勒技术评价DM患者左心室舒张功能具有临床应用价值,TE-e’可作为评价左心室舒张功能的重要参考指标;DM患者的病程及HbA1C的控制水平与左心室舒张功能密切相关。
To evaluate the value of left ventricular diastolic function in type 2diabetes mellitus（DM）using dual-gate Doppler and relative factors,we included 50non-obesity and hypertension-free DM patients into the controlled group in the study along with 48age-and-gender-matched healthy volunteer subjects.The peak early diastolic velocity（E）,peak later diastolic velocity（A）,deceleration time（DT）,anterior mitral annulus diastolic peak velocity（e＇）,isovolumic relaxation time（IVRT）,E/A,E/e＇,Tei index and TE-e＇were measured with dual-gate Doppler.20 subjects were randomly selected for repetitive analysis.Study showed statistical difference in E/A,DT,e＇,E/e＇,IVRT,Tei index and TE-e＇between the two groups（P〈0.05）.Linear regression analysis showed positive correlation between TE-e＇and IVRT,course of DM patients and TE-e＇（Beta=0.295,P=0.020）,and HbA1 Ccontrol level and TE-e＇（Beta=0.399,P=0.010）.Repeated analysis showed good reproducibility for both within and between groups.Dual-gate Doppler has clinical value in evaluating left ventricular diastolic function in type 2diabetes mellitus patients.The course of type 2diabetes mellitus patients and HbA1 Ccontrol level were both closely related with left ventricular diastolic function.
出处
《生物医学工程学杂志》
EI
CAS
CSCD
北大核心
2015年第1期163-167,共5页
Journal of Biomedical Engineering
关键词
糖尿病
双脉冲多普勒技术
左心室舒张功能
diabetes mellitus
dual-gate Doppler
left ventricular diastolic function
