摘要
目的 系统评估成纤维细胞生长因子受体2（fibroblast growth factor receptor 2,FGFR2）基因内含子的3个单核苷酸位点rs2981582、rs1219648和rs2420946多态性与中国人群乳腺癌的易感性的关系.方法 计算机检索PubMed、Embase、Co-chrane library、中国知网、维普、万方数据库及中国生物医学文献数据库中,2014-06-01之前关于FGFR2基因内含子的3个单核苷酸位点rs2981582、rs1219648和rs2420946多态性与中国人群乳腺癌易感性的相关研究,按纳入与排除标准筛选文献、提取资料并评价纳入研究的质量后,采用Stata 12.0软件进行Meta分析,计算合并OR值及其95％CI,并进行发表偏倚评估及敏感性分析.结果 共纳入18篇文献,包括14 568例患者和12 864名对照.Meta分析结果显示,FGFR2 rs2981582、rs1219648和rs2420946基因多态性与中国人群乳腺癌有显著相关性.以地域进行亚组分析,rs2981582的T等位基因在南方人群（OR=1.13,95％CI：1.06～1.22,P=0.001）和北方人群（OR=1.26,95％CI：1.06～1.49,P=0.008）中与乳腺癌显著相关;rs2420946的T等位基因在南方人群（OR=1.15,95％CI：1.08～1.23,P＜0.05）中与乳腺癌显著相关,北方人群中差异无统计学意义（OR=1.03,95％CI：0.87～1.22,P=0.695）;rs1219648的G等位基因在南方人群（OR=1.19,95％CI：1.10～1.28,P＜0.05）和北方人群（OR=1.17,95％CI：1.00～1.37,P=0.05）中与乳腺癌有显著相关.结论 FGFR2 rs2981582、rs1219648和rs2420946基因多态性与中国人群乳腺癌易感性显著相关,但以地域进行亚组分析时则表现有差异.
OBJECTIVE To evaluate the association between the fibroblast growth factor receptor 2 （FGFR2） gene polymorphism （rs2981582,rs1219648,rs2420946） and the breast cancer risk in the Chinese populations.METHODS All studies published up to June 2014 on the association between three functional polymorphisms （rs2981582,rs1219648,rs2420946） in the promoter of FGFR2 gene and susceptibility to breast cancer in Chinese population were collected by searching PubMed,Embase,Cochrane library,CNKI,VIP,Wanfang and CBD database.The data were screened according to the inclusion and exclusion criteria,and extracted,and the quality of included studies was evaluated.The pooled odds ratios （OR） with 95 ％ confidence intervals （95 ％ CI） were calculated using Stata 12.0 software.Publication bias and sensitivity analysis were also assessed.RESULTS A total of 18 case-control studies involving 14568 cases and 12864 controls were included in the Meta-analysis.The FGFR2 rs2981582,rs1219648,rs2420946 polymorphisms were significantly associated with breast cancer risk susceptibility among Chinese populations.The subgroup analysis by region revealed that significant risks were found in southern and northern China populations for rs2981582 T allele（southern：OR=1.13,95 ％CI：1.06-1.22,P =0.001 ; northern：OR =1.26,95％ CI..1.06-1.49,P =0.008）.Significant risks were found in southern China populations for rs2420946 T allele （OR=1.15,95 ％ CI：1.08-1.23,P＜0.05）,but not in northern China populations （OR=1.03,95 ％ CI：0.87-1.22,P =0.695）.Significant risks were found in southern and northern China populations for rs1219648 G allele（southern：OR=1.19,95％CI：1.10-1.28,P＜0.05; northern：OR=1.17,95％CI：1.00-1.37,P=0.05）.CONCLUSION The FGFR2 rs2981582,rs1219648,rs2420946 polymorphisms are significantly associated with breast cancer risk susceptibility among Chinese populations.
出处
《中华肿瘤防治杂志》
CAS
北大核心
2015年第3期227-234,共8页
Chinese Journal of Cancer Prevention and Treatment
