摘要
目的探讨金天格胶囊联合唑来膦酸治疗新疆维吾尔族骨质疏松症患者的临床疗效。方法选取2011年6月至2012年12月住院期间维吾尔族骨质疏松患者44例,年龄段为50-59岁,所有患者均初次诊断为骨质疏松症,未曾行任何抗骨质疏松治疗,同时排除其他骨代谢性疾病或药物影响,随机分为治疗组(23例,平均年龄56.3岁),给予唑来膦酸注射后辅以金天格胶囊,同时口服钙尔奇600 mg/d及罗盖全0.25 ug/d;对照组(21例,平均年龄57.1岁),对照组仅给予口服钙尔奇600mg/d及罗盖全0.25 ug/d,治疗时间一年,采用双能X线骨密度仪(DEXA)测定两组治疗前后的腰椎2-4、股骨颈、Ward’s三角区骨密度值。结果排除治疗组中2例患者脱失外,治疗组骨密度增幅程度均显著高于对照组(P<0.05)。结论金天格胶囊联合唑来膦酸可以明显增加新疆维吾尔族骨质疏松患者的骨密度,抑制骨量丢失,并且减少唑来膦酸不良反应的发生,此二者联合用药治疗骨质疏松安全、经济、高效。
Objective To investigate the efficacy of Jintiange capsule combined with zoledronic acid on the treatment of Uygur patients with osteoporosis in Xinjiang.Me thods Forty-four Uygur patients with osteoporosis in the hospital from June 2011 to December 2012,age from 50 to 59 years old,were selected.All the patients were diagnosed with osteoporosis first time,without any anti-osteoporosis treatment and no other bone metabolic diseases and drugs in use.They were randomly divided into treatment group( 23 cases,mean age 56.3 years) and control group( 21 cases,mean age 57.1 years).Patients in the treatment group received zoledronic acid injection and Jintiange capsules,600 mg / d oral calcium,and 0.25 ug / d Rocaltrol at the same time.Patients in the control group received 600 mg / d oral calcium,and 0.25 ug / d Rocaltrol.The treatment lasted for 1 year.Bone mineral density of the lumbar vertebrae 2-4, femoral neck, and Ward 's triangle was detected using dual-energy X-ray absorptiometry( DEXA) in the 2 groups before and after the treatment.Re sults The increase of BM D in the treatment was significantly higher than that in the control group( P〈0.05),excluding 2 patients drop-out in treatment group.Conclusion Jintiange capsule combined with zoledronic acid significantly increases BM D in Uygur patients with osteoporosis in Xinjiang,inhibits bone mass loss,and reduce the zoledronic acid-induced adverse reaction.The combination use in the treatment of osteoporosis is secure,economic,and efficient.
出处
《中国骨质疏松杂志》
CAS
CSCD
北大核心
2015年第1期80-83,共4页
Chinese Journal of Osteoporosis
基金
民政部"十一.五"课题的子课题(民人教科字(2007)18-1-39)
关键词
中医中药
金天格胶囊
唑来膦酸
骨质疏松
维吾尔族
骨密度
Chinese medcine and Chinese herb
Jintiange capsule
Zoledronic acid
Osteoporosis
Uygur
BMD