摘要
目的 观察圆锥角膜患者配戴1年以上RGPCL后的角膜形态、角膜厚度和角膜生物力学性能变化.方法 回顾性系列病例研究.选择诊断为中、重度圆锥角膜患者15例（30眼）,平均球镜度为（-9.53±3.60）D,平均散光度为（-3.42±2.13）D.为患眼验配RGPCL,采用配对t检验比较初诊和戴镜1年后球镜度和散光度,角膜平坦K值和陡峭K值,角膜厚度值及角膜黏滞性（CH）值和角膜阻力因子（CRF）值的差异.结果 戴镜1年以上,患眼角膜陡峭K值从（49.21±4.06）D降低至（47.95±3.16）D（t=3.156,P＜0.05）,角膜规则指数（SRI）及角膜不规则指数（SAI）分别从戴镜前的0.47±0.15和0.49±0.16降低至0.36±0.14和0.38±0.19（t=2.314、2.253,P＜0.05）.角膜散光度由（-3.42±2.13）D减小至（-2.63±1.57）D（t=-5.270,P＜0.01）.角膜厚度未见明显改变.角膜生物力学性能指标CH及CRF值分别由（8.26±0.39） mmHg和（7.53±0.56） mmHg上升至（10.23±0.49）mmHg和（9.05±0.58） mmHg（t=-5.954、-5.340,P＜0.01）.结论 中、重度圆锥角膜配戴RGPCL 1年后角膜生物力学性能指标随角膜形态规则化改变而升高.角膜生物力学性能可作为圆锥角膜配戴RGPCL后疗效及病情转归的重要判定指标。
Objective To observe the changes in corneal shape,corneal thickness and corneal biomechanics in keratoconus patients who wore RGPCL for more than 1 year.Methods In this retrospective case series study,15 patients （30 eyes） with moderate or worse keratoconus were recruited.Average spherical and astigmatic powers were-9.53±3.60 D and-3.42±2.13 D,respectively.The RGPCL were fitted for diagnosed keratoconus eyes,and a paired t-test was used to compare corneal parameters between before and after 1 year of lens wear.Measured parameters included spherical and astigmatism power,corneal fiat and steep K values,corneal thickness,corneal hysteresis （CH） and the corneal resistance factor （CRF）.Results Some changes occurred to keratoconus eyes after 1 year of wear：corneal steep K values decreased from 49.21±4.06 D to 47.95±3.16 D （t=3.156,P〈0.05）; the corneal surface regularity index （SRI） and surface asymmetry index （SAI） decreased from 0.47±0.15 and 0.49±0.16 to 0.36±0.14 and 0.38±0.19 （t=2.314,2.253,P〈0.05）; corneal astigmatism decreased from-3.42±2.13 D to-2.63±1.57 D （t=-5.270,P〈0.01）; corneal thickness had no significant change; corneal biomechanical CH increased from 8.26±0.39 mmHg to 10.23±0.49 mmHg （t=-5.954,P〈0.01）; and corneal biomechanical CRF increased from 7.53±0.56 mmHg to 9.05±0.58 mmHg （t=-5.340,P〈0.01）.Conclusion By following the change in corneal shape after 1 year of RGPCL wear,corneal biomechanical properties have significant increases in eyes with moderate or worse keratoconus.The patient＆#39;s condition and corneal biomechanics can be the key indicators for the efficacy of treating keratoconus patients with RGPCLs.
出处
《中华眼视光学与视觉科学杂志》
CAS
CSCD
2015年第1期14-17,共4页
Chinese Journal Of Optometry Ophthalmology And Visual Science
关键词
圆锥角膜
接触镜
硬性透气性
生物力学
角膜黏滞性
角膜阻力因子
Keratoconus
Contact lens,rigid gas-permeable
Biomechanics
Corneal hysteresis
Corneal resistance factor
