摘要
目的观察嗜酸乳杆菌片联合三联疗法治疗幽门螺杆菌(Hp)感染的疗效。方法 Hp感染患者258例随机分为三组,分别采用雷贝拉唑+克拉霉素+阿莫西林(三联组,86例)、三联组方案+复方嗜酸乳杆菌(益生菌组,85例)和三联组方案+铋剂(四联组,87例)治疗,测定各组胃黏膜IL-8表达,比较Hp根除率和不良反应发生情况。结果益生菌组Hp根除率为80.0%,高于三联组的60.5%(P<0.05)。益生菌组胃黏膜IL-8含量为(60.7±25.1)pg/ml,低于三联组的(73.1±27.7)pg/ml(P<0.05)。益生菌组腹泻、食欲减退、便秘等不良反应发生率低。结论嗜酸乳杆菌联合三联疗法能显著提高Hp根除率,减轻炎症反应,减少抗生素治疗相关不良反应。
Objective To investigate the efficacy of Lactobacillus acidophilus with triple therapy on Helicobacter pylori（Hp）infection.Methods A total of 258 patients with Hp infection was treated with triple therapy of rabeprazole,clarithromycin and amoxicillin（group A,86cases）,triple therapy plus Lactobacillus acidophilus（group B,85cases）and triple therapy plus bismuth potassium citrate（group C,87cases）.IL-8expression in gastric mucosa was detected.The eradication rate of Hp and drug side effects were compared.Results The eradication rate of Hp was higher in group B than that in group A（80.0% vs.60.5%）（P〈0.05）.IL-8expression in gastric mucosa was lower in group B than that in group A[（60.7±25.1）pg/ml vs.（73.1±27.7）pg/ml]（P〈0.05）.The incidence rates of diarrhea,astriction and anepithymia were low in group B.Conclusion Combined use of triple therapy and Lactobacillus acidophilus can improve the efficacy and reduce antibiotics-related adverse reactions in the treatment of Hp infection.
出处
《江苏医药》
CAS
2015年第2期168-170,共3页
Jiangsu Medical Journal
关键词
嗜酸乳杆菌
幽门螺杆菌
Lactobacillus acidophilus
Helicobacter pylori
