摘要
人参中的活性成分人参皂苷具有较好的生物活性和药理作用,疗效确切,毒副作用小,应用广泛,然而其易被胃酸分解、肠内菌群代谢,且肠黏膜通透性差,导致其口服生物利用度极低。本文对人参皂苷的口服给药药代动力学特点及体内生物转化作用进行了概述,并对其未来研究方向进行了展望,为今后的研究提供新的思路。
As an active component of Panax ginseng,ginsenosides has significantly biological activity and pharmacological action and may be used extensively because of its definite curative effect and mild side effect. However,ginsenoside with low membrane permeability is easy to be digested with gastric acid and metabolized with intestinal flora,resulting in its low bioavailability. This paper reviews the pharmacokinetics of oral administration and in vivo biotransformation of gin-senoside in recent years as well as the research area in future.
出处
《中国生物制品学杂志》
CAS
CSCD
2014年第12期1633-1636,共4页
Chinese Journal of Biologicals
基金
吉林省科技发展计划项目(20130101127JC)
长春市重大科技攻关计划项目(13KG6)
关键词
人参皂苷
口服生物利用度
体内转化
Ginsenosides
Oral bioavailability
In vivo biotransformation
