摘要
目的:探讨穴位针刺对行冠脉狭窄行搭桥手术患者转归及认知功能障碍发生率的影响。方法:选取我院近年来收治行冠脉狭窄行搭桥手术患者80例,采用随机数字表法分为对照组(40例)和试验组(40例);其中对照组患者行常规静脉吸入复合麻醉,不给予任何电针刺激;试验组患者则在行常规静脉吸入复合麻醉前和搭桥完成后给予电针刺激穴位;比较两组患者围手术期指标,术后认知障碍(POCD)发生率,不同时间点血清S100β蛋白和神经元特异性烯醇化酶(NSE)水平等。结果:两组患者手术时间和麻醉时间比较差异无统计学意义(P>0.05);试验组患者机械通气时间、ICU时间及住院时间均显著少于对照组,差异有统计学意义(P<0.05);对照组和试验组患者POCD发生率分别为57.50%(23/40),12.50%(5/40);试验组患者POCD发生率显著低于对照组,差异有统计学意义(P<0.05);两组患者术前S100β和NSE水平比较差异无统计学意义(P>0.05);试验组患者手术完成时、术后6 h及术后12 h S100β和NSE水平均显著低于对照组,差异有统计学意义(P<0.05)。结论:穴位针刺用于行冠脉狭窄行搭桥手术患者可有效改善疾病转归,降低认知功能障碍发生风险,具有临床应用价值。
Objective： To investigate effects of acupuncture on coronary artery stenosis underwent bypass operation for patients＇ prognosis and postoperative cognitive dysfunction. Methods： 80 patients with coronary artery stenosis underwent bypass operation were chosen in recent years in our hospital and randomly divided into two groups including control group（ 40 patients） with conventional intravenous and inhalation anesthesia without electroacupuncture stimulation and experiment group（ 40 patients） with electroacupuncture stimulation before conventional intravenous and inhalation anesthesia and after bypass completion. And the perioperation period index,incidence of postoperative cognitive dysfunction（ POCD）,levels of serum S100 β protein at different time points and neuron specific enolase（ NSE） of both groups were compared. Results： There was no significant difference in operation time and anesthesia time between 2 groups（ P 〉0. 05）. The mechanical ventilation time,ICU time and hospitalization time of experiment group were statistically significant shorter than those of control group（ P 〈0. 05）. The incidences of POCD of control group and experiment group were separately 57. 50%（ 23 /40）,12. 50%（ 5 /40）. The incidence of POCD of experiment group was significantly lower than that of control group（ P〈 0. 05）. There was no significant difference in levels of serum S100 β protein and NSE before operation between 2 groups（ P 〉0. 05）. The levels of serum S100 β protein and NSE of experiment group were significantly lower than those of control group in operation completion,6 h and 12 h after surgery（ P 〈0. 05）. Conclusion： Acupuncture on coronary artery stenosis underwent bypass operation can effectively improve prognosis,reduce the risk of POCD and has value of clinical application.
出处
《中华中医药学刊》
CAS
北大核心
2015年第2期472-474,共3页
Chinese Archives of Traditional Chinese Medicine
关键词
针刺
冠状动脉搭桥
转归
认知功能障碍
acupuncture
coronary artery stenosis underwent bypass operation
prognosis
postoperative cognitive dysfunction
