摘要
目的:探讨腹腔镜与经腹子宫全切术对机体免疫功能的影响。方法:选择70例有子宫全切除术适应证的患者,随机分为腹腔镜子宫全切术组(TLH组)和开腹子宫全切术组(TAH组),每组各35例,比较两组患者围手术期指标及手术前后C-反应蛋白(CRP)、T淋巴细胞亚群的动态变化。结果:TLH组术中出血量及术后肛门排气时间均显著少于TAH组(P<0.05);TLH组术后各时间点CRP水平均明显低于TAH组(P<0.05);TAH组患者CD3+、CD4+、CD4+/CD8+水平在术后1天和3天均较术前明显降低(P<0.05),且低于TAH组(P<0.05);TLH组术后免疫功能各指标与术前相比差异无统计学意义(P>0.05)。结论:腹腔镜子宫全切术具有机体创伤小、应激反应小、对免疫功能影响小及术后恢复快的优点,值得临床进一步推广应用。
Objective： To explore the effects of total laparoscopic hysterectomy （TLH） and total transabdominal hysterectomy （TAH） on immune function. Methods： Seventy patients with indications for hysterectomy were randomly divided into TLH group and TAH group, 35 patients in each group. Perioperative indicators and dynamic changes of C -reactive protein （CRP） and T lymphocytes subgroups before and after operation in the two groups were compared. Results： The amount of blood loss and postoperative exhausting time in TLH group were statistically significantly less than those in TAH group （ P 〈 0. 05 ） ; CRP levels at different time points in TLH group were statisti- cally significantly lower than those in TAH group （ P 〈 0. 05 ） ; CD3＋, CD4 ＋ and CD4＋/CD8＋ levels on the first day and the third day after operation in TAH group were statistically significantly lower than those before operation in TAH group and TAH group （ P 〈 0. 05 ） ; in TLH group, there was no statistically significant difference in indicators of immune function between before and after operation （ P 〉 0. 05 ） . Conclusion ： TLH has the advantages of little surgical trauma, small stress response, small impact on immune function and rapid postopera- tive recovery, which is worthy of further clinical popularization and application.
出处
《中国妇幼保健》
CAS
2015年第6期964-966,共3页
Maternal and Child Health Care of China
