摘要
一氧化氮（nitric oxide,NO）是近年来眼科疾病的研究热点.其在体内一氧化氮合酶（nitric oxide synthase,NOS）的催化下生成,作为一种小分子介质调节眼部血流.诸多脉络膜视网膜疾病如葡萄膜炎、青光眼、缺血-再灌注损伤、前部缺血性视神经病变、糖尿病视网膜病变以及视网膜色素变性等发病机制中均发现NO的异常,与NO相拮抗的内皮素-1（Endothelin-1,ET-1）也日益受到关注.对NO合成途径的干预有望成为一种新的眼科治疗手段.
In recent years it has been recognized that nitric oxide（NO） is a hot spot in research of ocular diseases.As a molecular medium synthesized by nitric oxide synthase （NOS）.NO is involved in the control of ocular blood flow.Abnormalities of NO system have been observed in a variety of ocular diseases including uveitis,glaucoma,retinal ischemic diseases,diabetic retinopathy and retinitis pigmentosa.In addition,its antagonist endothelin-1 （ET-1） also attracts much attention.All these make the nitric oxide pathway an attractive target for therapeutic interventions of ocular diseases.
出处
《国际眼科纵览》
2014年第6期420-424,共5页
International Review of Ophthalmology
基金
国家自然科学基金（81271046）
关键词
一氧化氮
一氧化氮合酶
眼疾病
nitric oxide
nitric oxide synthase
ocular diseases
