摘要
目的观察连花清瘟颗粒联合利巴韦林和康复新液治疗疱疹性口腔炎的临床疗效。方法选择2012年1-10月份在医院儿科门诊进行诊治的疱疹性口腔炎的患儿80例,完全随机平分为治疗组和对照组各40例,2组除给予维生素C和维生素B2等支持、对症治疗以外,均给予利巴韦林注射液静脉滴注10-15mg·kg^-1·d^-1,分2次给药和口服康复新液,〈3岁患儿每次5ml,〉3岁患儿每次10ml,均3次/d,治疗组患儿在此治疗基础上加用连花清瘟颗粒口服（石家庄以岭药业股份有限公司,6g/袋）,≤3岁3g/次,3次/d;〉3岁6g/次,3次/d,均治疗5d10结果治疗组总有效率为97.5%明显高于对照组的87.5%（P〈0.01）,治疗组热退时间,口腔炎疱疹溃疡愈合时间为（1.4±0.7）d、（2.9±0.6）d比较对照组的（3.2±1.2）d、（3.7±0.9）d明显缩短,差异有统计学意义（P〈0.01）。结论连花清瘟颗粒联合利巴韦林和康复新液治疗疱疹性口腔炎,能迅速缓解临床症状,疗效确切,值得临床推广和应用。
Objective To observe the clinical efficacy of Lianhuaqingwen particles combined with ribavirin and Kangfuxinye fluid in treatment of herpetic stomatitis. Methods 80 cases of children with herpetic stomatitis in outpatient de- partment of Pediatrics of our hospital were randomly divided equally into treatment group and control group ,each of 40 cases. In addition to giving vitamin C and vitamin B2 and other support, symptomatic therapy, both groups were given ribavirin intrave- nous injection 10- 15mg·kg^-1·d^-1） ,in 2 divided doses and oral Kangfuxinye under 3 years old per 5ml,3 years old per 10ml were 3 times a day. The treatment group based on the use of this treatment were given Lianhuaqingwen oral granules（ Shi- jiazhuang Yiling Pharmaceutical Co. ,Ltd. ,6g/bags ）, ≤ 3 years per 3g,3 times a day; 〉3 aged per 6g,3 times a day. Both groups were treated for 5 days. Results The total effective rate was 97.5 % in the treatment group, which was higher than 87.5% of the control group, and the difference was statistically significant （P 〈 0.01 ） ;the heat back time, stomatitis herpes sores healing time of the treatment group was significantly shorter than the control group[ （ 1.4 ± 0.7） d ratio（3.2 ± 1.2）d, （2.9 ± 0. 6） d ratio （ 3.7 ± 0.9） d, both P 〈 0.01 ], and the difference was statistically significant （ P 〈 0.01 ）, Conclusion Lianhuaqingwen particles combined with ribavirin treatment and Kangfuxinye can quickly relieve symptoms in the treatment of herpetic stomatitis, with exact effect,which is worthy of clinical promotion and application .
出处
《临床合理用药杂志》
2015年第5期42-43,共2页
Chinese Journal of Clinical Rational Drug Use
