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清君泻心汤治疗支气管哮喘心火亢盛证20例临床观察 被引量:6

Clinical Observation on 20 Cases of Bronchial Asthma with Excessive Heart Fire Syndrome Treated with Qingjun Xiexin Decoction
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摘要 目的观察清君泻心汤治疗支气管哮喘心火亢盛证的临床疗效。方法将40例支气管哮喘心火亢盛证患者随机分为治疗组和对照组各20例。治疗组给予布地奈德福莫特罗粉吸入剂每次1吸,每日2次;并联合清君泻心汤每日1剂口服治疗。对照组给予布地奈德福莫特罗粉吸入剂联合清君泻心汤安慰剂治疗。两组疗程均为4周。疗程结束后比较两组哮喘控制水平分级、哮喘控制测试(ACT评分)、中医证候积分、肺功能[包括一秒用力呼气容积(FEV1)、呼气峰流量(PEF)]、血清总Ig E、血嗜酸性粒细胞计数(EOS)及中医证候疗效。结果两组患者哮喘控制水平分级比较差异无统计学意义(P>0.05)。两组治疗后与本组治疗前比较,ACT评分提高,中医证候积分降低,FEV1及PEF增加,血EOS及血清总Ig E降低(P<0.05);两组治疗后组间比较,治疗组中医证候积分及血清总Ig E较对照组下降明显(P<0.05)。治疗组中医证候疗效临床痊愈3例,显效8例,有效6例,无效3例,总有效率85%;对照组临床痊愈1例,显效4例,有效7例,无效8例,总有效率60%,两组比较差异有统计学意义(P<0.05),治疗组优于对照组。结论清君泻心汤治疗支气管哮喘心火亢盛证临床疗效肯定,可明显改善患者临床症状,降低血清总Ig E。 Objective To observe the clinical efficacy of Qingjun Xiexin Decoction on bronchial asthma patients with excessive heart fire syndrome. Methods Forty bronchial asthma patients with excessive heart fire syndrome were randomly divided into treatment group and control group,with 20 cases in each. The treatment group was given budesonide and formoterol fumarate powder for inhalation,1 suction per time,2 times a day,and Qingjun Xiexin Decoction 1 dose daily,while the control group was given the same inhalation therapy with the treatment group and the placebo of Qingjun Xiexin Decoction,all for 4 weeks. After the treatment,asthma controlled levels,ACT scores,TCM syndrome scores,pulmonary function including forced expiratory volume in one second( FEV1),peak expiratory flow( PEF),total serum Ig E,blood eosinophil count( EOS),and the therapeutic efficacy of TCM syndromes were compared between the two groups. Results There was no significant difference in the asthma controlled levels between the two groups( P〉0. 05). The ACT scores improved,TCM syndrome scores,serum EOS and Ig E levels decreased,and FEV1 and PEF increased in both groups after the treatment( P〉0. 05). The TCM syndrome scores and serum total Ig E in the treatment group were significantly lower than those in the control group after treatment( P〈0. 05).Observation on the efficacy of TCM syndromes showed that there were 3 cases( 15%) of clinical recovery,8 cases( 40%) with marked effects,6 cases( 30%) with normal effects,and 3 cases( 5%) with no effects in the treatment group( total efficiency of 85%),while there was 1 case( 5%) of clinical recovery,4 cases( 20%) with marked effects,7 cases( 35%) with normal effects,and 8 cases( 40%) with no effects in the control group( total efficiency of 60%),with a statistically significant difference between the two groups( P〈0. 05). Conclusion By improving clinical symptoms and reducing serum total Ig E,Qingjun Xiexin Decoction shows a promising c
出处 《中医杂志》 CSCD 北大核心 2015年第4期319-322,共4页 Journal of Traditional Chinese Medicine
关键词 支气管哮喘 哮病 清君泻心汤 心火亢盛证 bronchial asthma asthma disease Qingjun Xiexin Decoction excessive heart fire syndrome
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