摘要
1-磷酸鞘氨醇(sphingosine-1-phosphate,S1P)是一种具有生物活性的细胞膜的重要组成部分以及鞘脂类代谢产物之一。S1P也是调节细胞内外多种生物学功能的重要信号分子,通过与5种G蛋白偶联受体亚型结合(即S1PR1-S1PR5)产生不同的生物学功能,包括调节细胞增殖、存活、凋亡、炎症诱导及血管再生等。近年来研究表明S1P及其S1PR/SPHK对肺部疾病的发生发展起着重要的作用,尤其对支气管哮喘、肺纤维化、肺炎、支气管扩张、慢性阻塞性肺病(chronic obstructive pulmonary disease,COPD)以及肺癌的发生发展起着关键的作用,这或许为肺部疾病的治疗提供一个新途径。
Sphingosine-1-phosphate is one of the important components of a biologically active membrane and sphingolipid metabolites. It is important signaling molecules which regulates many biological functions in intracellular and extracellular. SIP combining with five kinds of G protein-coupled receptor subtypes （SIPR1-SIPR5） have different biological functions, including the regulation of cell proliferation, survival, apoptosis, inflammation and angiogenesis. Recent studies show that S1P and SIPR/SPHK play the important role in the development of lung disease, especially in bronchial asthma, pulmonary fibrosis, pneumonia, bronchiectasis, chronic obstructive pulmonary disease （COPD） and lung cancer. These studies may provide a new approach for the treatment of lung diseases.
出处
《临床与病理杂志》
CAS
2015年第1期111-117,共7页
Journal of Clinical and Pathological Research
基金
国家自然基金项目(81270093)
湖南省科技计划项目(2012FJ3075)
湖南省自然科学基金(12JJ3111)
湖南省医药卫生科研计划课题(B2013-064)~~
关键词
1-磷酸鞘氨醇
鞘氨醇激酶
支气管哮喘
肺纤维化
肺炎
支气管扩张
慢性阻塞性肺病
肺癌
sphingosine-l-phosphate （SIP）
sphingosine kinase
bronchial asthma
pulmonary fibrosis
pneumonia
bronchiectasis
chronic obstructive pulmonary disease
lung cancer.
