摘要
研究发现部分患者对氯吡格雷存在药物抵抗现象,其中功能缺失等位基因CYP2C19*2的作用最为显著。基因检测目前被逐步用于临床,旨在帮助医师发现并改善因携带功能缺失等位基因引起的血小板高反应性及临床不良事件。现就基因检测的临床真实疗效做一概述。
Some research has shown that in patients with clopidogrel resistance,loss of function allele CYP2C19＊ 2 may play a significant role. Identifying links like this through genetic testing is gradually being used as a diagnostic tool in the clinic. Genetic testing can help physicians find and improve treatment by identifying alleles that loss of function. This paper reviews the effect of genetic testing in antiplatelet therapy in the clinic.
出处
《心血管病学进展》
CAS
2015年第1期23-26,共4页
Advances in Cardiovascular Diseases
基金
"十二.五"国家科技支撑计划项目(2011BAI11B07)
国家自然科学基金资助项目(81170194)
