摘要
目的探究马来酸依那普利叶酸片联合抗利尿激素受体拮抗剂对行急诊经皮冠状动脉介入治疗(PCI)的急性心肌梗死(AMI)患者心功能、N末端B型利钠肽原(NT-proBNP)、C反应蛋白(CRP)、同型半胱氨酸(Hcy)及白细胞介素(IL)-6的影响。方法分析2017年1月至2019年3月该院行急诊PCI的AMI患者76例为研究对象,按照实际治疗情况将患者分为对照组(n=45)和观察组(n=31),对照组给予马来酸依那普利叶酸片治疗,观察组在对照组治疗的基础上给予抗利尿激素受体拮抗剂治疗。对比两组临床治疗效果、心功能、NT-proBNP、CRP、Hcy、IL-6水平。结果治疗后,对照组与观察组总有效率分别为71.11%、96.77%,对照组总有效率明显低于观察组,差异有统计学意义(χ^2=24.421,P<0.001)。治疗后,两组患者左室射血分数、心输出量水平明显升高,纽约心脏病协会分级Ⅱ级人数比例明显增加,且观察组上述指标治疗前后变化均较对照组更为明显,差异有统计学意义(P<0.05)。两组治疗前后左室舒张末期内径水平比较,差异无统计学意义(P>0.05)。治疗后,两组NT-proBNP、CRP、Hcy和IL-6水平均明显下降,且观察组上述各指标水平变化较对照组更明显,差异有统计学意义(P<0.05)。结论马来酸依那普利叶酸片联合抗利尿激素受体拮抗剂治疗行急诊PCI的AMI患者效果明显,且能明显改善心功能,降低血清NT-proBNP、CRP、Hcy、IL-6水平,值得临床推广。
Objective To investigate the effects of enalapril maleate and folic acid tablets combined with antidiuretic hormone receptor antagonists on cardiac function,N-terminal B type natriuretic peptide prosoma(NT-proBNP),C-reactive protein(CRP),homocysteine(Hcy)and interleukin(IL)-6 in patients with acute myocardial infarction(AMI)undergoing emergency percutaneous coronary intervention(PCI).Methods A total of 76 patients with AMI who underwent emergency PCI in Shiyan People′s Hospital from January 2017 to March 2019 were recruited into this study.The patients were divided into control group(n=45)and observation group(n=31)according to the actual treatment situation.Patients in control group were treated with enalapril maleate and folic acid tablets,and patients in observation group were given antidiuretic hormone receptor antagonist therapy on the basis of control group.The clinical effects,cardiac function,NT-proBNP,CRP,Hcy and IL-6 levels of the two groups were compared.Results After treatment,the total effective rates in control group and observation group were 71.11%and 96.77%respectively,the rate in control group was significantly lower than that in observation group(χ^2=24.421,P<0.001).After treatment,left ventricular ejection fraction and cardiac output,the percentage of New York heart association classificationⅡcases increased significantly in two groups,the changes of these indexes before and after treatment in observation group were more obviously than those in control group,the differences were statistically significant(P<0.05),but there was no significant difference on left ventricular end-diastolic diameter(P>0.05).After treatment,the levels of NT-proBNP,CRP,Hcy and IL-6 in both groups significantly decreased,and the changes of the above indicators in observation group were more significant than those in control group(P<0.05).Conclusion Enalapril maleate and folic acid tablets combined with antidiuretic hormone receptor antagonists has significant effect on patients with AMI undergoing emergency PCI,an
作者
丁进叶
谭艳杰
姚玲玲
龚勇
金银生
DING Jinye;TAN Yanjie;YAO Lingling;GONG Yong;JIN Yinsheng(CCU,Shiyan People′s Hospital/People′s Hospital Affiliated to Hubei Medical College,Shiyan,Hubei 442000,China)
出处
《国际检验医学杂志》
CAS
2020年第22期2788-2791,共4页
International Journal of Laboratory Medicine
关键词
急诊
经皮冠状动脉介入治疗
急性心肌梗死
N末端B型利钠肽原
emergency
percutaneous coronary intervention
acute myocardial infarction
N-terminal B type natriuretic peptide prosoma
