摘要
目的探讨γ干扰素释放分析试验在肺结核病中的诊断价值。方法选取2013年5~11月首都医科大学附属北京胸科医院菌阳肺结核患者和菌阴肺结核患者各120例,结核病患者密切接触者、健康志愿者各40例,同时行γ干扰素释放分析试验,以酶联免疫斑点技术法检测结核分枝杆菌感染T细胞（T-SPOT.TB检测）,比较各组检出阳性率。结果γ干扰素释放分析试验诊断肺结核病的敏感性为87%（208/240）,对结核病患者密切接触者的特异性为55%（22/40）,健康志愿者的特异性为100%（40/40）。结论γ干扰素释放分析试验对肺结核病的诊断具有较高的敏感性和特异性。
Objective To investigate the diagnostic value of interferon-γ release assay in pulmonary tuberculosis patients. Methods One hundred and twenty cases of sputum positive pulmonary tuberculosis patients and 120 smear-negative pulmonary tuberculosis patients, 40 close contacts of patients with tuberculosis and 40 cases of healthy volunteers in May-November 2013 in Beijing Chest Hospital were included into this study. An ELISPOT-based interfer-on-γrelease assay （T-SPOT.TB） was tested at the same time. SPSS 17.0 statistical software was used for statistical analy-sis. Chi-square test and paired Chi-square test were used to detect the positive rate. Results The sensitivity of interfer-on-γ release assay in pulmonary tuberculosis patients was 87%（208/240）, the specificity of close contacts of patients with tuberculosis was 55% （22/40）, the specificity was 100% （40/40） for healthy volunteers. Conclusion Interferon-γ release assay has high sensitivity and specificity for the diagnosis of pulmonary tuberculosis.
出处
《北京医学》
CAS
2015年第2期112-114,共3页
Beijing Medical Journal
基金
北京市科技计划(Z121100005512008)
关键词
γ干扰素释放分析试验
肺结核病
诊断
结核菌素皮肤试验
Interferon-γrelease assay
Pulmonary tuberculosis
Diagnosis
Tuberculin skin test
Interferon-γrelease assay
Pulmonary tuberculosis
Diagnosis
Tuberculin skin test
