摘要
目的研究伊曲康唑治疗真菌性角膜炎临床效果,为合理用药提供参考依据。方法选择2011年3月-2014年2月收治的36例真菌性角膜炎患者为观察组,采用伊曲康唑+两性霉素B+氟康唑滴眼液治疗,回顾性调查2005年3月-2011年3月收治的36例真菌性角膜炎患者临床资料为对照组,给予两性霉素B+氟康唑滴眼液治疗,连续治疗1个月后对两组治疗效果进行评估并记录。结果治疗有效率观察组为97.2%、对照组为88.9%,治疗有效率观察组高于对照组,差异有统计学意义(P<0.05);观察组患者的角膜溃疡、前房积脓、畏光流泪恢复时间均明显短于对照组,差异有统计学意义(P<0.05);两组患者在治疗过程中均无明显不良反应发生。结论在两性霉素B和氟康唑的基础上加用伊曲康唑治疗真菌性角膜炎效果,优于仅应用两性霉素B和氟康唑,且可缩短治疗所需时间,治疗安全性较好,值得临床推广。
OBJECTIVE To observe the effect of itraconazole applied in treatment of fungal keratitis so as to provide reference of rational administration.METHODS Totally 36 cases of patients diagnosed as fungal keratitis from Mar.2011 to Feb.2014 were selected as the observation group,and itraconazole,amphotericin B and fluconazole eye drops were applied.Another 36 cases of patients diagnosed as fungal keratitis during Mar.2005 to Mar.2011 were selected as the control group,and only amphotericin B and fluconazole eye drops were applied.The effect was assessed and recorded after treating for a month.RESULTS The efficient rate in the observation group was97.2%,higher than 88.9%in the control group,with statistical significance（P〈0.05）.The recovery time of corneal ulcers,hypopyon,photophobia and tearing in the observation group was shorter than that in the control group,with statistical significance（P〈0.05）.No significant adverse reaction was found during treatment in both groups.CONCLUSIONS The effect of application of amphotericin B combined with fluconazole plus itraconazole was better than combination use of amphotericin B and fluconazole,and the treatment time could be shortened with high safety,which was worthy of clinical promotion.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2015年第4期833-835,共3页
Chinese Journal of Nosocomiology
基金
江山市科技局基金资助项目(2013F05)
