摘要
目的明确兰索拉唑临床应用和不良反应,为药物的应用范围及其安全性问题提供文献依据和研究思路。方法对近十几年来兰索拉唑国内外相关临床药理作用和不良反应报道进行整理、归纳与分析。结果兰索拉唑常用于十二指肠溃疡、胃溃疡、反流性食管炎、卓-艾综合征等各种消化功能紊乱性疾病,其疗效高,不良反应少。结论建议在临床应用兰索拉唑时,应严格按照药品说明书和相关指南,对症用药,控制用药剂量与疗程,减少药品不良反应发生,注重联合用药尤其是中西药物联合用药的指征、用法、用量、疗程的研究,提高用药合理性和有效性。
Objective To explore the clinical applications and adverse reactions of lansoprazole and provide literature basis and idea for the application range and safety issues of lansoprazole. Methods References in the last decades at home and abroad about the clinical pharmacological actions and adverse reactions oflansoprazole were collated, analyzed and summarized. Results Lansoprazole is always used to treat the diseases of duodenal ulcer, gastric ulcer, reflux esophagitis, Zollinger-Ellison syndrome and other digestive function disorder diseases. Compared with other proton- pump inhibitors, lansoprazole has the advantages of higher curative effect and less adverse reactions. Conclusion We＇d better be in accordance with the drug instructions or under the guidance of pharmacist when lansoprazole has to be used for the corresponding disease. The dosages and treatment course should be controlled to reduce adverse reactions. At the same time, the researches of indication, usage, dosage and treatment course of lansoprazole combined with Chinese herbs and/or western medicine should be paid more attention to improve its rationality and effectiveness.
出处
《中国药物警戒》
2014年第12期729-731,共3页
Chinese Journal of Pharmacovigilance
基金
国家重大新药创制科技重大专项课题:中药复方药理学研究及药效学评价关键技术(2009ZX09502-015)
注射用兰索拉唑技术升级及增加临床适应症的研究(2014ZX09201-003-001)
关键词
兰索拉唑
质子泵抑制剂
消化功能紊乱性疾病
不良反应
lansoprazole
proton-pump inhibitor
digestive function disorder disease
adverse reaction
