摘要
目的：通过检测中重型颅脑损伤后脑脊液及血清中S100B蛋白随时间的水平变化,研究血清及脑脊液中S100B蛋白水平变化的相关性。方法：选取对照组人群48例,测定其血清及脑脊液中S100B蛋白水平。选取中重度颅脑损伤患者（GCS 6-12分）96例,分别于伤后的1、3、5、7、14、21 d取血及脑脊液,检测其S100B水平,比较伤后不同时间的S100B蛋白水平的变化。结果：中重型颅脑损伤后患者血清及脑脊液（Cerebrospinal fluid,CSF）中S100B蛋白水平随时间不断变化的,CSF和血清S100B蛋白峰值均发生在伤后第1天和第3天,各时间点CSF和血清S100B蛋白水平均高于健康对照组,差异有统计学意义（P〈0.05）,且伤后一段时间内CSF和血清S100B蛋白水平存在一定的相关性。结论：伤后早期脑脊液和血清S100B蛋白水平彼此密切相关,但是随着时间的推移这种相关性逐渐减低。
Objective：To detect the S100 B protein change levels in cerebrospinal fluid（Cerebrospinal fluid,CSF） and serum after moderate and severe craniocerebral injury to study the time correlation of levels in cerebrospinal fluid and serum. Method：48 cases were selected as the control group, the levels of S100 B protein in serum and cerebrospinal fluid were determined. 96 patients with moderate and severe craniocerebral injury（GCS 6-12 scores） were selected, their serum and cerebrospinal fluid were collected and the concentration of S100 B protein,1,3,5,7,14,21 d respectively after injury were detected.Result：After moderate and severe craniocerebral injury,the levels of S100 B protein in the serum and Cerebrospinal fluid of patients changed with time. The peaks of S100 B protein in CSF and serum were both occurrrd at the first day and the third day after injury, CSF and serum S100 B protein levels were higher than control group, the difference was statistically significant（P〈0.05） at each time points, the S100 B protein levels in CSF and serum existed a certain correlation after a period time of injury.Conclusion：The levels of S100 B protein in cerebrospinal fluid and serum are closely related with each other, but this correlation gradually reduced as the time gone by.
出处
《中国医学创新》
CAS
2015年第3期10-12,共3页
Medical Innovation of China
基金
青海省自然科学基金项目(2013-Z-918)
关键词
颅脑损伤
血清
脑脊液
S100B蛋白
Craniocerebral injury
Serum
Cerebrospinal fluid
S100B protein
