摘要
目的观察光动力联合改性几丁质治疗生殖道尖锐湿疣（CA）的疗效、安全性以及治疗后HPV基因型随访。方法将64例生殖道尖锐湿疣患者分两组，每组32例，观察组采用改性几丁质联合光动力治疗3—5次，观察两组疗效、复发率、不良反应等；每例患者首次治疗前，疗程结束时，脱落细胞送检HPV基因亚型。结果观察组和对照组治愈率分别为96．86％和84．36％，差异无统计学意义（P〉0．05）；复发率分别为3．23％和25．93％，不良反应率分别为0和31．25％，差异有统计学意义（P均〈0．05）；两组共8例复发，8例治疗前检查和随访第1次复查均为阳性，第2次、第3次复查仍然有部分病例持续阳性，其中6例为多重型别的高危型感染，随访见高危型HPV33和HPV16持续感染。结论改性几丁质联合光动力治疗对于生殖道尖锐湿疣的患者，可降低其复发率、减少其术后不良反应率；CA患者术后复查检测HPV—DNA的意义更大。
Objective To observe the efficacy and safety of photodynamic therapy combined with chitin modified treatment of genital warts and implement the HPV genotype follow-up after treatment. Methods Sixty-four cases of genital condyloma acuminatum patients were divided into two groups, with 32 patients in each group. The patients in observation group were treated by modified chitin combined with photodynamic therapy for 3～5 times. The curative effect, recurrence rate, adverse reaction of patients in both groups were observed, and HPV subtypes of detached cells were also inspected before and after treatment. Results The cure rates of observation group and the control group were 96.86% and 84.36% respectively, without statistical difference （P 〉 0.05）. Recurrence rates of both groups were 3.23% and 25.93% respectively, and the adverse reaction rates of both groups were 0 and 31.25% respectively with statistical difference（ all P 〈 0.05 ）. Total 8 patients recurred in both groups were continuously positive in HPV examination before treatment and follow-up review and 6 patients were multiple-high-risk infection of HPV33 and HPV16. Conclusion Treatment of modified chitin combined with photodynamic therapy for genital condyloma acuminata patients, can reduce the relapse rate and the adverse reaction rate after operation;There was more important to inspect HPV-DNA of patients with CA after operation.
出处
《中国皮肤性病学杂志》
CAS
CSCD
北大核心
2015年第1期53-55,共3页
The Chinese Journal of Dermatovenereology
关键词
尖锐湿疣
光动力疗法
几丁质
Condyloma acuminatum
Photodynamic therapy
Chitin
