摘要
目的:检测女性尖锐湿疣(CA)皮损中人乳头瘤病毒(HPV)的基因型。方法:采用Hybri-Max技术,对116例女性尖锐湿疣患者皮损组织进行HPV感染分型检测。结果:HPV阳性107例,共发现20种HPV亚型;单一型别阳性率是51%(59/116),以低危型HPV11,6为主。多重基因型别阳性率是41.2%(48/116)。高危型HPV检出率为47%(55/116),多重感染率达到87%(48/55);高危型与低危型HPV感染在皮损类型、病变部位无差异。结论:深圳市女性尖锐湿疣以低危型HPV11、6型感染为主;高危型感染多以混合感染形式存在。
Objective： To detect papillomavirus （HPV） genotypes in female patients with condyloma acuminate （CA）. Methods： HPV genotypes were detected by HybriMax technique in 116 female patients with CA. Results： Out of 116 clinical samples HPV were detected in 107 samples, with a positivity rate of 92.2%, including 20 HPV subtypes. The single type of HPV was found in 51% of the samples, mainly being low risk type （HPV11,6）, and multiple types of HPV in 41.2%. The detection rate of high risk type of HPV was 47% （55/116）, of which 87% （48/55） were multiple infection. The clinical form of the lesion and the site of the lesion were not associated with high or low risk subtype of HPV. Condusion： In the current group of patients the infection mainly is low risk type of HPV （HPV11,6）, while the infection of high risk type of HPV exists in a mixed infection with other HPV types.
出处
《中国麻风皮肤病杂志》
2011年第7期471-473,共3页
China Journal of Leprosy and Skin Diseases
关键词
人乳头瘤病毒
尖锐湿疣
基因芯片
papillomavirus, human
condyloma, acuminate
HybriMax
