摘要
目的:本文对红景天注射液和聚乙二醇重组人粒细胞集落刺激因子对麻醉犬心脏血流动力学及心肌耗氧量进行分析,探讨二者心血管药理作用的不同机制。方法:将实验犬20只随机分为四组:对照组、红景天注射液、聚乙二醇重组人粒细胞集落刺激因子组及盐酸地尔硫卓注射剂组。实验犬经麻醉戊巴比妥麻醉后(i.v.)开胸,分别测定各组心输出量、左室内压上升最大速率、冠脉阻力、总外周阻力、心肌耗氧量。结果:本研究发现红景天注射液可增强心输出量,差异具有统计学意义(P<0.05);降低心肌耗氧量、冠脉阻力及总外周阻力,差异具有统计学意义(P<0.05);对左室内压上升最大速率和心脏指数无明显影响(P>0.05),而聚乙二醇重组人粒细胞集落刺激因子对上述指标无明显影响(P>0.05)。结论:红景天注射液通过调整心肌供氧量及降低心脏后负荷发挥药理作用,而聚乙二醇重组人粒细胞集落刺激因子无明显的即刻作用。
Objective： The present investigation aimed to explore the effect of Hongjingtian injection and PEG-rhC-CSF on cardiac hemodynamics and myocardial oxygen consumption of anesthetized dogs. Methods： Dogs were divided into 4 groups randomly, control, Hongjingtian group, PEG-rhG-CSF group and positive control. The cardiac output, dp/dtmax, coronary resistance, total peripheral resistance and myocardial oxygen consumption were detected. Results： The cardiac output was in- creased while coronary resistance, total peripheral resistance and myocardial oxygen consumption were decreased greatly （P〈 0.05） in Hongjingtian group when compared with control. But dp/dtmax and cardiac index were not influenced in Hongjingtian group. These parameters were not changed in PEG-rhG-CSF group when compared with control （P〉0. 05）. Conclusion：Hongjingtian but not PEG-rhG-CSF exerts pharmaceutical effect by regulating myocardial oxygen consumption and afterload in heart.
出处
《海南医学院学报》
CAS
2015年第3期316-318,322,共4页
Journal of Hainan Medical University
基金
武汉科技计划资助项目(2012c251)~~
