摘要
目的观察安心颗粒对麻醉犬心脏血流动力学及心肌耗氧量的影响。方法采用麻醉犬在体心脏实验方法,经十二指肠给予安心颗粒,于给药后不同时间点,用RM-6300型八道生理记录仪测定心脏血流动力学和心肌耗氧量。结果安心颗粒能够降低总外周阻力、左室内压最大上升速率(+LVdp/dtmax)及心肌耗氧量,而其他血流动力学指标无明显变化。结论安心颗粒可通过降低心脏后负荷和心肌收缩力,从而减少心肌耗氧量,对缺血心肌具有保护作用。
Objective To study the effect of A nxin Granula on the cardiohemodynamics and myocardial oxygen con-sumption in anesthetized dogs. Methods Experimental technology for in-vivo anesthetized dog heart was adopted. Af-ter A nxin Granula was administrated to the anestheticzed dogs through the duodenum, the parameters of cardiohemo-dynamics and oxygen consumption of the dogs were determined at different time point. Results The total peripheral resistance, the maximum increase velocity of left ventricular pressure （＋LVdp/dtmax） and oxygen consumption of my-ocardium were decreased, hut other indexes showed no significant change. Conclusion A nxin Granula can decrease the myocardial oxygen consumption by reducing cardiac after-load and myocardial contractility in anesthetized dogs, therefore has protective effect on the ischemic myocardium.
出处
《中药新药与临床药理》
CAS
CSCD
北大核心
2013年第3期255-257,共3页
Traditional Chinese Drug Research and Clinical Pharmacology
基金
广西科技攻关项目(0235023-4)
关键词
安心颗粒
心脏血流动力学
心肌耗氧量
犬
A nxin Granula
Cardiohemodynamics
Myocardial oxygen consumption
Dogs
