摘要
肠易激综合征(irritable bowel syndrome,IBS)是一种常见的功能性肠病,包含有肠组织中某些炎症细胞因子的表达增高以及部分肠道和躯体敏感性增高的现象.最新的研究表明微小RNA(micro RNAs,mi RNAs)介导了疾病的炎症、神经性疼痛、内脏和躯体化高敏感等病理过程,本文以IBS的各种病理过程作为切入点,对相关mi RNAs在IBS中出现的异常表达以及mi RNAs对IBS的各种病理过程的可能的介导机制进行综述,并探讨mi RNAs作为生物标志物和治疗靶点在诊断和治疗IBS中的应用前景.
Irritable bowel syndrome （IBS） is a common functional bowel disorder characterized by elevated inflammatory cytokines in the intestinal tissue and increased intestinal and somatic sensitivity. The latest research shows that microRNAs （miRNAs） mediate the pathological process of inflammation, neuropathic pain, visceral and somatic hypersensitivity. This review aims to elucidate the dysregulated expression of miRNAs in IBS and their possible pathological mechanism and discuss their application in the diagnosis and treatment of IBS as biomarkers and therapeutic targets.
出处
《世界华人消化杂志》
CAS
北大核心
2014年第35期5460-5466,共7页
World Chinese Journal of Digestology
基金
国家自然科学基金资助项目
No.81273839~~
关键词
Micro
RNA
肠易激综合征
内脏炎症
内脏高敏感
5-羟色胺
MicroRNAs
Irritable bowel syndrome
Visceral inflammation
Visceral hypersensitivity
5-hydroxytryptamine
