摘要
肠易激综合征(IBS)是临床最常见的功能性肠病,其病因及发病机制还不完全清楚。5-羟色胺(5-HT)是参与调节胃肠道运动和分泌功能的重要神经递质,在IBS的发病中有重要意义。5-羟色胺转运体(SERT或5-HTT)蛋白再摄取神经突触间隙的5-HT,对其起灭活作用。大量研究表明,SERT基因多态性与IBS各型间可能存在联系。
IBS is the most common functional gastrointestinal（G1） disease, which etiopathogenisis is not completely understood. As a key neurotransmitter modulating GI motility and secretion, serotonin plays critical an role in the complex pathophysiology of the IBS. SERT can reuptake 5-HT from nerve synaptic space and terminate its actions, Many researches suggest that the possible relationship exists between serotonin transporter gene polymorphism and the subtypes of IBS.
出处
《国际消化病杂志》
CAS
2008年第5期364-367,共4页
International Journal of Digestive Diseases
