摘要
目的探讨益生菌制剂对溃疡性结肠炎(UC)患者肠黏膜的修复作用。方法 84例UC患者按照随机、双盲原则分为研究组(n=42)与安慰剂组(n=42)。安慰剂组给予美沙拉嗪或激素治疗;研究组在安慰剂治疗基础上,加用双歧杆菌、嗜酸乳杆菌、肠球菌三联活菌制剂治疗。分别于治疗前、治疗后1、3、6个月行肠镜检查,根据肠镜下表现进行评分。结果治疗后1、3、6个月,研究组肠黏膜评分为(1.86±0.68)、(1.28±0.46)、(0.82±0.24)分,均较安慰剂组的(2.48±0.86)、(1.84±0.74)、(1.26±0.58)分显著降低(P<0.05或P<0.01)。结论益生菌制剂联合应用有助于UC患者肠黏膜修复。
Objective To explore the repair effects of probiotic preparation on intestinal mucosa of patients with ulcerative colitis（ UC）. Methods Total 84 patients with UC were selected and divided into research group and placebo group（ n = 42,respectively） on principles of random and double blind. The placebo group was provided with mesalazine or hormone therapy,based on which,the research group was provided with Bifidobacterium,Lactobacillus acidophilus,and Enterococcus triple viable capsules. And then,colonoscopy was performed in both groups respectively before the treatment,and within one month,three months,and six months after the treatment,and intestinal mucosa scoring were made according to the endoscopic performance. Results Within one month,three months,and six months after the treatment,the intestinal mucosa scores in the research group（ 1. 86 ± 0. 68,1. 28 ± 0. 46,and0. 82 ± 0. 24,respectively） decreased significantly（ P〈 0. 05 or P〈 0. 01） in comparison with those in the placebo group（ 2. 48 ± 0. 86,1. 84 ± 0. 74,and 1. 26 ± 0. 58,respectively）. Conclusion Combined administration of probiotic preparation is helpful for repair of intestinal mucosa of patients with UC.
出处
《西南国防医药》
CAS
2015年第1期24-26,共3页
Medical Journal of National Defending Forces in Southwest China
关键词
溃疡型结肠炎
益生菌
肠黏膜
ulcerative colitis
probiotics
intestinal mucosa
