摘要
目的系统评价中国人群食用蔬菜及水果与鼻咽癌之间的关系及关联强度,为我国鼻咽癌的防治策略提供依据。方法系统检索CNKI、万方和维普3个中文数据库及PudMed、ScienceDirect和SpringerLink 3个英文数据库2013-03之前发表的鼻咽癌病例对照研究及队列研究。文献检索、选取、信息提取及质量评价（NOS评分）均由2人独立进行。采用基于方差倒数加权的随机效应模型计算合并的OR值及相应95%的置信区间（95%CI）。结果共有11篇病例对照研究纳入最终的分析,包括2篇高质量的研究和9篇中等质量的研究,共涉及来自全国5个省份的鼻咽癌患者4 162例,对照4 588例。在合并所有研究之后发现,食用蔬菜与鼻咽癌发病风险之间存在显著的负相关,OR=0.52,95%CI：0.27-0.77;I^2=82.8%,P〈0.001;N=5;而食用绿色蔬菜与鼻咽癌发病风险的OR=0.59,95%CI：0.36-0.82;I^2=89.2%,P〈0.001;N=7。同时,食用水果与鼻咽癌发病风险的OR=0.63,95%CI：0.56-0.70;I^2=0,P=0.506;N=8。基于发表偏倚检验的结果提示,除绿色蔬菜与鼻咽癌发病风险的纳入研究之间存在潜在的发表偏倚外,尚不能认为其他两项Meta分析纳入研究之间存在潜在的发表偏倚。结论在中国,食用蔬菜及水果,尤其是食用蔬菜,均有可能降低鼻咽癌的发病风险,未来应该强调食用蔬菜及水果在对我国鼻咽癌预防中的保护作用。
OBJECTIVE To evaluate the relationship and the strength of association for vegetable and fruit consumption witb. the risk of nasopharynx cancer among Chinese population, provide evidences for developing strategies of preventing nasopharynx cancer in China. METHODS A systematic search of 3 Chinese electronic databases （CNKI, VIP, Wanfang） and 3 English database （Pubmed, ScienceDirect, SpringerLink） up to March 2013 was performed. Two reviewers independently conducted the literature search, study eligibility, data extraction and quality evaluation. Pooled odds ratio （OR） value and 95% CI were calculated with random-effects model weighted with inverse of variances. RESULTS Eleven case-control studies （2 high quality studies and 9 modest quality studies） involving 4 162 cases of nasopharynx cancer and 4 588 controls from 5 provinces were included in this review. There was a significant inverse association between vegetable consumption and the risk of nasopharynx cancer among Chinese population, with OR of 0. 52（95%CI： 0. 27-0. 77;I2 =82.8% ,P〈0. 001;N=5）. Compared with the non-consumption of green vegetable, the risks of nasopharynx cancer for regular consumption of green vegetable was 0. 59 （95% CI： 0. 36-0. 82;I^2= 89.2%,P〈 0. 001;N=7）. The association of fruit consumption with the risks of nasopharynx cancer was 0. 63 （95%CI： 0.56- 0. 70;I^2= 0,P= 0. 506;N= 8）. Although there was potential publication bais among the included studies focus on the assocaition between consumption of green vegetable and the risks of nasopharynx cancer, no potiential publication bais was found among the other two meta-analysis. CONCLUSIONS In China, both consumption of vegetable and fruit, espacially the vegetable, could decrease the risk of nasopharynx cancer. Further plans on the prevention of nasopharynx cancer in China should emphasis the the protective effects of vegetable and fruit.
出处
《中华肿瘤防治杂志》
CAS
北大核心
2014年第23期1914-1919,1924,共7页
Chinese Journal of Cancer Prevention and Treatment
基金
首都医科大学附属北京儿童医院科研项目(2012ZD01)
国际科技合作与交流专项(2012DFG31620)
关键词
鼻咽肿瘤
食用蔬菜
食用水果
META分析
Nasopharynx cancer
Vegetable consumption
Fruit consumption
Meta-analysis
