β痕迹蛋白与心血管疾病的研究进展被引量：1

β-trace protein and cardiovascular disease

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摘要 β痕迹蛋白(β-trace protein,BTP)亦称为lipocalin型前列腺素D合酶(1ipocalin-type prostagladin D synthase,L-PGDS),是一种糖基化、双功能单体蛋白质,具有催化前列腺素D2(PGD2)的合成和转运亲脂性物质的作用。近年研究显示,BTP具有抗炎症、抗血栓形成、抗细胞凋亡、抗动脉粥样硬化等心血管保护作用,可作为多个心血管疾病的良好标志物。本文就BTP在心血管疾病中的最新研究进展作一综述。 Summary β-trace protein, known as lipocalin type prostaglandin D synthase, is a N-glycosylated dual functional monomeric protein, and acts as a PGD2 producing enzyme and also as a lipophilic ligand-binding protein. More recently, BTP was found to have cardiovascular protection, such as antiatherogenic,antithrombogenic, anti- apoptotic, and antiinflammatory effects, and acts as good predictor to several cardiovascular disease. This article reviews the advanced research of BTP in cardiovascular disease.

作者陈云宪唐良秋

机构地区粤北人民医院心内科

出处《临床心血管病杂志》 CAS CSCD 北大核心 2014年第12期1025-1029,共5页 Journal of Clinical Cardiology

关键词 β痕迹蛋白 lipocalin型前列腺素D合酶心血管疾病 β-trace protein lipocalin type prostaglandin D synthase-cardiovascular disease

分类号 R34 [医药卫生—基础医学]

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