摘要
目的观察并探讨依帕司他联合甲钴胺治疗2型糖尿病(T2DM)周围神经病变(DPN)的疗效并神经电生理变化。方法入选2012年7月-2013年6月间收治的110例T2DM合并DPN患者为研究对象,随机分为观察组(57例)与对照组(53例),对照组给予甲钴胺营养神经,观察组在此基础上加服依帕司他片,疗程均为12周,对比两组治疗后神经电生理变化情况与临床疗效。结果治疗后,两组患者正中神经、腓总神经感觉传导速度(SNCV)、运动传导速度(MNCV)均较治疗前显著改善,观察组治疗后正中神经、腓总神经SNCV[(7.3±5.6)m/s、(6.9±5.2)m/s]、MNCV[(50.5±5.7)m/s、(47.3±5.1)m/s]均显著高于对照组SNCV[(44.5±4.8)m/s、(43.4±4.9)m/s]、MNCV[(47.6±5.4)m/s、(45.2±4.8)m/s](P<0.05)。两组疗效构成不同(Z=2.198,P=0.028),观察组总体有效率(86.0%)明显高于对照组(67.9%)(χ2=5.090,P=0.024)。治疗期间,未见明显肝肾功能异常与其他不良反应。结论依帕司他联合甲钴胺治疗T2DM伴DPN患者,作用互补,可显著改善神经传导,提高临床疗效。
[ Objective ] To observe and explore clinical elhcacy and neural electrophyslology variation on Lpalre- stat combined with methylcobalamin in treatment of diabetic peripheral neuropathy（DPN） in type 2 diabetes. [Meth- ods] 110 admitted cases with DPN of Jul.2012-Jun.2013 were selected as study objects, and were randomized into observer group （57 cases） and control group （53 cases）, control group was applied with methylcobalamin therapy, based on which Epalrestat was added to observer group, 12 weeks for a course, after which neural electrophysiology variation and clinical efficacy were noted and compared. [ Results ] After treatment, sensory nerve conduction veloci- ty （SNCV） and motor nerve conduction velocity （MNCV） for median nerve and common peroneal nerve were signifi- cantly improved compared with pretreatment, SNCV [（7.3±5.6） m/s, （6.9±5.2 m/s）], MNCV[（50.5±5.7） m/s, （47.3±5.1） m/s] for median nerve and common peroneal nerve of observer group were significantly higher than those of control group SNCV[（44.5±4.8） m/s, （43.4±4.9） m/s], MNCV[（47.6±5.4） m/s, （45.2±4.8） m/s]（P 〈0.05）. The efficacy composi- tions of 2 groups were different （Z =2.198, P =0.028）, total effective rate of observer group （86%） was significantly higher than control group （67.9%）（X2=5.090, P =0.024）. During treatment, there were no obvious abnormality of liver ＆ kidney functions and other adverse reactions. [ Conclusions ] Epalrestat combined with Methylcobalamin in treat- ment of T2DM patients with DPN whose effieacies are complementary, can significantly improve nerve conduction, promote clinical efficacy.
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2014年第36期77-80,共4页
China Journal of Modern Medicine
