摘要
目的：了解甲钴胺联合丹参川芎嗪在治疗糖尿病周围神经病变中的作用，为该病提供有效而可靠的治疗方法。方法163例糖尿病周围神经病变被随机分为观察组86例和对照组77例，观察组采用甲钴胺联合丹参川芎嗪治疗，对照组仅采用甲钴胺治疗。在治疗前后测定两组的腓总神经、正中神经的感觉传导速度（SNCV）和运动传导速度（MNCV）；治疗1个疗程后评定治疗效果。结果两组治疗后的 SNCV、MNCV 均高于治疗前，差异均有统计学意义（t ＝24．298、25．546、18．737、15．733、14．284、14．886、9．337、9．402，均 P ＜0．05）；观察组治疗后的 SNCV、MNCV 均高于对照组，差异均有统计学意义（t ＝9．119、11．103、7．429、6．352，均 P ＜0．05）。观察组的显效率48．8％（42／86），总有效率90．7％（78／86），均高于对照组，差异均有统计学意义（χ2＝9．010、7．937，均 P ＜0．05）。观察组的药物不良反应发生率5．8％（5／86），对照组的药物不良反应发生率6．5％（5／77），差异无统计学意义（χ2＝0．033，P ＞0．05）。结论在治疗糖尿病周围神经病变中，甲钴胺联合丹参川芎嗪具有更好的疗效，药物不良反应发生率较低，具有良好的临床应用价值。
Objective To learn therapeutic effect of the combined treatment of mecobalamin and salvia miltiorrhiza ligustrazine on diabetic peripheral neuropathy.To provide effective and reliable operation method for the treatment of disease.Methods 163 cases with diabetic peripheral neuropathy were randomly divided into observation group（86 cases）and control group（77 cases）.The observation group was treated with mecobalamin combined salvia miltiorrhiza ligustrazine,the control group was treated with mecobalamin.The sensory conduction velocity （SNCV） and motor conduction velocity （MNCV）were measured in the two groups before and after treatment.The therapeutic effects were evaluated after one course.Results The MNCV and SNCV of the two groups were higher than before treatment,the difference was statistically significant （t =24.298,25.546,18.737,15.733,14.284,14.886,9.337, 9.402,all P 〈0.05）.The SNCV and MNCV in the observation group were significantly higher than those in the control group （t =9.119,11.103,7.429,6.352,all P 〈0.05）.The markedly effective rate of the observation group was 48.8% （42 /86）,the total effective rate was 90.7% （78 /86）,which were higher than those of the control group,the differences were statistically significant （χ2 =9.010,7.937,all P 〈0.05）.The incidence rate of adverse reaction of the observation group was 5.8% （5 /86）,which of the control group was 6.5% （5 /77）,the difference was not statistically significant （χ2 =0.033,P 〉0.05）.Conclusion In the treatment of diabetic peripheral neuropathy,the com-bined treatment of mecobalamin and salvia miltiorrhiza ligustrazine has better curative effect and low incidence rate of adverse reaction,with good clinical application value.
出处
《中国基层医药》
CAS
2015年第22期3467-3469,共3页
Chinese Journal of Primary Medicine and Pharmacy
关键词
甲钴胺
丹参川芎嗪
糖尿病周围神经病变
感觉传导速度
运动传导速度
Mecobalamin
Salvia miltiorrhiza ligustrazine
Diabetic peripheral neuropathy
Sensory nerveconduction velocity （SNCV）
Motor nerve conduction velocity （MNCV）
