摘要
目的分析胸腺肽联合化疗对老年胃癌患者免疫功能及Th1、Th2细胞因子含量的影响。方法选择在河南科技大学第一附属医院接受住院治疗的老年胃癌患者作为研究对象,随机分为接受单独化疗的对照组和接受胸腺肽联合化疗的观察组,比较两组患者的T细胞亚群水平、Th1及Th2细胞因子含量、血清MMP水平等差异。结果观察组患者接受治疗后的NK细胞、CD3+、CD4+水平明显高于对照组(P<0.05),CD8+水平与对照组患者无明显差异(P>0.05)。观察组患者接受胸腺肽联合化疗后IFN-γ、TNF-α水平高于对照组,IL-4、IL-10水平低于对照组(P<0.05)。观察组患者接受胸腺肽联合化疗后的血清MMP-2及MMP-9水平均显著低于对照组患者(P<0.05)。结论胸腺肽联合化疗有助于提升老年胃癌患者的免疫功能,提高Th1因子含量,降低Th2因子及血清MMP水平。
[Objeetive] To analyze effect of thymopeptides combined chemotherapy on elderly stomach cancer pa- tients＂ immune function and Thl, Th2 cytokines content. [Methods] 98 cases of elderly gastric cancer patients were chose, randomly divided into control group received chemotherapy alone and observation group with thymopeptides combined chemotherapy. The levels of T cell subsets and Thl and Th2 cytokines levels, serum levels of MMPS were compared. [Results] The levels of NK cells, CD3~,CD4~ in observation group were significantly higher than that in control group （P 〈0.05）, CD8~ level were no difference （P 〉0.05）. The levels of IFN-＇,/, TNF-ct in observation group were higher than that in control group, IL-4, IL-IO level were lower（P 〈0.05）. The levels of MMP-2 and MMP-9 in observation group were significantly lower than that in control group （P 〈0.05）. [ Conclusions ] Thymopeptides was helpful to improve the immune function in elderly patients with gastric cancer, increasing content of Thl factor, re- duce the Th2 factor and serum levels of MMP.
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2014年第36期51-54,共4页
China Journal of Modern Medicine
关键词
胃癌
胸腺肽
化疗
免疫功能
gastric cancer
thymopeptides
chemotherapy
immune function
