摘要
目的探讨胸腺肽联合化疗治疗老年胃癌患者的疗效及其对细胞免疫、Th1、Th2细胞因子、基质金属蛋白酶(MMP)水平的影响。方法将80例老年胃癌患者根据随机数字表法分为观察组和对照组,每组40例,2组患者均给予常规FOLFOX4化疗方案治疗,在此基础上,观察组患者给予胸腺肽治疗,连续治疗28 d后比较2组临床疗效,对比2组治疗前后T细胞亚群、肿瘤坏死因子-α(TNF-α),干扰素-γ(IFN-γ)和白细胞介素-4(IL-4)、白细胞介素-10(IL-10)、MMP-2、MMP-9的变化。结果观察组治疗总有效率为75.00%,显著高于对照组的52.50%,差异有统计学意义(P<0.05);治疗后观察组CD3^+、CD4^+、TNF-α、IFN-γ均较治疗前和对照组显著升高,IL-4、IL-10显著降低,差异有统计学意义(P<0.05),而2组治疗前后CD8+比较差异无统计学意义(P>0.05);2组治疗后MMP-2、MMP-9均较治疗前显著降低,且观察组降低更明显,与对照组比较差异有统计学意义(P<0.05)。结论胸腺肽联合化疗治疗可以提高老年胃癌患者的免疫功能,调节Th1/Th2平衡,降低肿瘤的浸润与转移,具有重要的临床意义。
Objective To explore the effects of thymopeptide combined with chemotherapy on cellular immunity, Th1 ,Th2 cytokines, matrix metallo proteinase （MMP） levels in patients with gastric cancer. Methods Eighty elderly patients with gastric cancer were divided into observation group and control group according to random number table method, with 40 cases in each group. Patients in two groups were given routine FOLFOX4 chemotherapy treatment, and the patients in the observation group were treated with thymopeptide additionally. After 28 days＇ treatment, the clinical effect between two groups were compared. And the levels of T cell subsets and Th1 cytokines such as： tumor necrosis factor-α （TNF-α）, interferonγ（IFN-γ） and Th2 cytokines such as： interleukin 4 （IL-4）, interleukin 10 （IL-10）, MMP-2, MMP-9 before and after treatment were detected and compared between two groups. Results The total effective rate in observation group was 75.00%, which was significantly higher than that in control group（52. 50%, P〈0. 05） ; The levels of CD3^＋ ,CD4^＋ ,TNF-α,IFN-γ after treatment in observation group were significantly increased than those before treatment and those in the control group after treatment, while the levels of IL-4, IL-10 were decreased significantly （P〈0. 05） ; After treatment, the levels of MMP-2 and MMP-9 in two groups were significantly reduced, and the levels of MMP-2 and MMP-9 in observation group were significantly lower than those in the control group （P〈 0. 05）. Conclusions Thymopeptide combined with chemotherapy can improve the immune function, adjust Th1/Th2 balance, reduce the invasion and metastasis of tumor in the elderly patients with gastric cancer.
出处
《实用老年医学》
CAS
2016年第6期479-482,共4页
Practical Geriatrics
