摘要
目的探讨单胺氧化酶A(monoamine oxidase A,MAOA)rs1137070基因多态性与儿童期躯体受虐因素的交互作用对酒精依赖患者家庭暴力行为的影响。方法对284例新疆地区酒精依赖患者进行问卷调查,通过家庭暴力问卷调查表获得社会人口学资料、施暴(有或无)及施暴的表现形式,采用修改版外显行为攻击量表和修订版Barratt冲动量表对攻击行为进行评估并分组,采用儿童受虐筛查表与儿童受虐量表联合调查儿童期躯体受虐情况。直接测序法检测患者MAOA基因rs1137070位点的多态性。根据叉生分析相加模型交互作用指标判断基因与儿童期躯体受虐因素的交互作用。结果施暴组和对照组分别为146例和138例患者。儿童期受虐与rs1137070位点等位基因是新疆汉族及维吾尔族酒精依赖患者家庭暴力行为的危险因素。儿童期受虐与rs1137070等位基因存在相加模型正交互作用,两者的超额相对危险度、交互作用归因比、交互作用指数分别为1.00、0.14和1.20。结论新疆汉族及维吾尔族酒精依赖患者家庭暴力行为的发生是儿童期受虐因素及遗传危险因素共同作用的结果,儿童期受虐因素与rs1137070等位基因共同影响家庭暴力行为的发生。
Objective To investigate the effects of the interaction between environmental factors and monoamine oxidase A （MAOA） gene polymorphism in Han and Uygur on alcoholics in Xinjiang. Methods The data of childhood abuse and domestic aggressive behaviors were collected from 284 patients with alcohol dependence from Xinjiang using self-made questionnaires, Modified Overt Aggression Scale （MOAS） and Barratt Impulsivity Scale-11 （BIS-11）. The methods of PCR and DNA sequencing technique were conducted to detect rs1137070 single nucleotide polymorphism loci of MAOA gene. Logistic regression analysis was performed to adjust for interaction effects of gene and childhood abuse on domestic violence. Results The scale evaluation identified 143 patients with and 138 patients without domestic violence. Childhood abuse and gene were both risk factors in domestic violence. The interaction effect of childhood abuse with rs1137070 was significant. the relative excess risk, the interaction attribution ratio and the interaction index were 1.00,0.14 and 1.20, respectively. Conclusions The interactions between genes and environmental risk factors may contribute to the domestic violence in Han and Uygur on alcoholics in Xinjiang.
出处
《中国神经精神疾病杂志》
CAS
CSCD
北大核心
2014年第10期580-584,共5页
Chinese Journal of Nervous and Mental Diseases
基金
国家自然科学基金项目(编号:31060137)
关键词
暴力行为
单胺氧化酶A
儿童期躯体受虐
交互作用
Violent behavior
Monoamine oxidase A
childhood physical abuse
Interaction effects
