摘要
探索了以丙二酸单乙酯、3-氨基丙酸乙酯盐酸盐为原料合成2,4-哌啶二酮,再与N-甲基-2-苯肼反应生成目标分子2,3,4,5-四氢-5-甲基-1H-吡啶并[4,3-b]吲哚-1-酮和盐酸阿洛司琼的合成方法,总收率为30.2%.此方法反应速率快、产率高、适用于大规模生产.
The synthesis method was used to obtain 2, 3, 4, 5-tetrahydro-5-methyl-1H-pyrido[4, 3-b]indol-1-one and alosetron hydrochloride from N-methyl-2-phenylhydrazine and 2, 4-piperidine-dione was synthesized with malonate and 3-amino-propionic acid ethyl ester hydrochloride. The overall yield of the compound was 30.2%The methods had a rapid reaction rate, high yield and were applicable in industrial production.
出处
《兰州大学学报（自然科学版）》
CAS
CSCD
北大核心
2014年第6期902-906,共5页
Journal of Lanzhou University(Natural Sciences)
基金
甘肃省科技厅国际科技合作专项项目(1204WCGA020)
甘肃省科技厅创新团队建设计划项目(1207TTCA009)
关键词
哌啶二酮
吲哚
盐酸阿洛司琼
合成
高产率
piperidinedione
indole
alosetron hydrochloride
synthesis
high yield
