摘要
目的:评价麻醉诱导期使用小剂量右美托咪定预处理对舒芬太尼诱发呛咳的抑制作用。方法:105例全麻下行甲状腺次全切除手术患者被随机分成三组。对照组、实验组1(D1组)和实验组2(D2组)在麻醉诱导期分别接受生理盐水、0.25μg/kg右美托咪定和0.5μg/kg右美托咪定静脉注射。输注完毕后3组患者均给予0.3μg/kg舒芬太尼静脉注射。记录注射芬太尼后1 min内呛咳的发生情况和强度;记录各组从静脉输注右美托咪定到气管插管后1 min期间的BP和HR。结果:3组呛咳发生率分别为27.0%、8.3%和6.2%。与对照组相比,D1组和D2组的呛咳总发生率和中、重度呛咳发生率明显减少(P<0.05)。与对照组相比,D1组低血压和心动过缓的发生率无明显增加(P>0.05),但D2组的心动过缓发生率较对照组增多(P<0.05)。结论 :麻醉诱导期静脉注射小剂量右美托咪定可抑制舒芬太尼诱发呛咳,使气管插管更平稳。
Objective To investigate the effect of pretreatment with a small dose of dexmedetomidine on sufentanil-induced eoughduring anesthetic induction. Methods Onehundred and five patients undergoing elective subtotal thyroideetomy under general anesthesiawere were randomized into 3 groups （n = 37 in the control group, n = 36 in D1 group and n = 32 in D2 group）. Dexmedetomidine with the dose of 0, 0.25, and 0.5 μg/kg was administered in 5 rain to the control group, group D1 and group D2, respectively, followed by the induction of general anesthesia within travenous propofol, with a target concentration of 1 mg/mL, and sufentanil 0.3 μg/kg, respectively. The incidences and severity of cough that occurred within 1 min after the injection of sufentanil were recorded, and the incidences of cardiovascular adverse events that occurred between the administration of the dexmedetomidine infusion and 1 rain after tracheal intubation were also recorded. Results The incidences of cough in the three groups were 27.0%,8.3% and 6.2% respectively. The incidence was significantly lower in group D1 and group D2 than that in control group. The incidence of severe sinus bradycardia in group D2 was higher than that in the control grouop, while there was no significant difference between the control group and group D1. No significant differences in the incidence of low blood pressure were found among the three groups. Conclusion Dexmedetomidine with the dose of 0.25, and 0.5 μg/kg could significantly reduce the incidence of sufentanil-induced cough during anesthetic induction, especially with the dose of 0.25 μg/kg.
出处
《实用医学杂志》
CAS
北大核心
2015年第1期122-124,共3页
The Journal of Practical Medicine
基金
广东省自然科学基金资助(编号:S2012040006569)
关键词
右美托咪定
舒芬太尼
呛咳
麻醉诱导
Dexmedetomidine
Sufentanil
Cough
Anesthetic induction
