摘要
目的探讨番茄红素对心肌缺血模型大鼠的保护机制。方法采用结扎左冠状动脉前降支法建立大鼠心肌缺血模型,观察番茄红素不同剂量组对心肌缺血大鼠心肌梗死面积(MIS)的影响,及对血清乳酸脱氢酶(LDH)、肌酸激酶同工酶(CK-MB)、超氧化物歧化酶(SOD)、丙二醛(MDA)及谷胱甘肽过氧化物酶(GSH-PX)含量的影响。结果各给药组MIS均显著小于模型组(P<0.01),番茄红素高剂量组MIS显著小于低剂量组及丹参组(P<0.05);模型组血清LDH、CK-MB、MDA含量较假手术组显著升高(P<0.01),番茄红素高剂量组及丹参组均显著低于模型组(P<0.05或P<0.01);模型组血清SOD、GSH-PX含量较假手术组显著降低(P<0.05),番茄红素高剂量组SOD含量显著高于模型组(P<0.05)。结论番茄红素对缺血心肌具有保护作用,其机理可能与其降低心肌酶含量及机体氧化应激水平有关。
Objective To explore the protective effect of lycopene on myocardial ischemia in rats and its mechanism. Methods Myocardial ischemia model was established by ligation of left anterior descending coronary artery. The influences of different doses of lycopene on myocardial infarct area （MIS）, serum lactate dehydrogenase （LDH）, creatine kinase isoenzyme （CK-MB）, superox- ide dismutase （SOD）, malondialdehyde （MDA） and glutathion peroxidase （GSH- PX） were ob- served. Results MIS in model group was significantly bigger than the rest groups（P〈 0.01）, and MIS in lycopene high-dose group was significantly smaller than those in lycopene low-dose group and salvia miltiorrhiza group （P 〈 0.05）. LDH, CK-MB and MDA were evidently higher in model group than in sham - operated group, lycopene high - dose group and salvia miltiorrhiza group （ P 〈 0.05 or P 〈 0.01 ）, while SOD and GSH-PX in model group were obviously lower than those in sham-operated group. SOD in lycopene high-dose group was significantly higher than that in model gtoup（P 〈 0.05）. Conclusion Lycopene can protect ischemic myocardium. Its mechanism may relate to the reduction of myocardial enzyme and oxidative stress level.
出处
《实用临床医药杂志》
CAS
2014年第24期4-6,共3页
Journal of Clinical Medicine in Practice
基金
中国高校医学期刊临床专项资金(11321462)
