摘要
目的:通过对Ski相关蛋白(Ski-interacting protein,SKIP)在乳腺癌中的研究,讨论其与乳腺癌发生发展的关系及其对乳腺癌患者预后判断的意义。方法:收集90例住院患者乳腺癌及癌旁组织,免疫组织化学法测定SKIP的表达水平,结合临床病理资料,分析其在乳腺癌中的意义。结果:SKIP在乳腺癌中高表达,且SKIP的表达与乳腺癌的组织分化程度(P=0.01),雌激素受体(P=0.024)及孕激素受体(P=0.046)有关,与其他临床病理参数无关。而乳腺癌中Ki-67的表达与SKIP结果相似。相关性分析表明乳腺癌组织中SKIP的表达与Ki-67的表达呈正相关(r=0.585,P=0.004)。多因素分析发现:组织分化程度、Ki-67和SKIP的表达与患者的总生存率均有明显的相关性。结论:SKIP是一个新发现的乳腺癌相关蛋白,在评估乳腺癌的侵袭和转移潜能中起重要作用,还可成为乳腺癌的一个潜在的治疗靶点。
Objective： Through the research to examine the expression of the Ski-interacting protein（SKIP） in breast cancer,its relationship with the occurrence and development of breast cancer and its prognostic significance in patients with breast cancer was discussed. Methods： Immunohistochemical analysis was performed in 90 human breast carcinoma samples and the adjacent normal tissues for detecting the expression of SKIP. Then the data were correlated with clinicopathological features to analyze its significance in breast cancer. Results： SKIP was highly expressed in breast carcinoma tissues compared with the adjacent normal tissues. SKIP expression was significantly associated with histologic grade（P=0.01）,ER status（P=0.024） and PR status（P=0.046）,but there was no correlation between SKIP expression and other factors. Meanwhile Ki-67 expression obtained similar results. There was also a marked correlation between SKIP and Ki-67 expression（r=0.585,P=0.004）. Multiariable analysis found that tissue differentiation degree,the expression of Ki-67 and SKIP had obvious correlation with the overall survival of patients. Conclusion： SKIP is a novel breast cancer associated protein which may play an important role in evaluating invasion and metastatic potentiality in breast cancer. SKIP may serve as a potential therapeutic strategy for breast cancer.
出处
《南通大学学报（医学版）》
2014年第6期485-488,共4页
Journal of Nantong University(Medical sciences)
基金
南通市社会事业科研创新与示范计划(HS2014047
HS2014050)
关键词
乳腺癌
Ski相关蛋白
预后
breast cancer
Ski-interacting protein
prognosis
