摘要
目的探讨重症慢性心力衰竭患者的个体化药物治疗效果。方法随机选取2013年1月-2014年1月来我院就诊的重症慢性心力衰竭患者50例。根据患者的个体情况,对患者给予不同种类和剂量的利尿剂、血管扩张剂、醛固醇类、血管紧张素Ⅱ受体拮抗剂等药物的治疗。对患者在治疗前后治疗的显效、有效、无效情况进行分析;记录患者在住院第一周、第二周、第三周和第四周的入院住院费用,并计算人均日住院费用;对患者在治疗前后的心率值、收缩压、舒张压、LVEF、LVDD等情况进行分析。结果患者治疗后显效例数为35例,有效例数为14例,无效例数为1例,总的治疗有效率达到98%;患者在治疗后,心率、收缩压、舒张压、LVDD、LVEF等指标都有了显著的改善,差异显著,P<0.05;患者在住院第一周花费的费用最大,并且随着病情的逐渐好转,患者花费的住院费用逐渐下降,差异显著,P<0.05;人均日住院费用随着治疗时间的增加逐渐下降,差异显著,P<0.05。结论重症慢性心力衰竭患者在治疗时,应该进行个体化药物治疗,以最大程度地较少患者的治疗费用,并达到最好的治疗效果。
Objective To investigate efficacy of personalized medication for severe chronic heart failure. Methods Fifty patients with severe chronic heart failure who were admitted to our hospital from January 2013 to January 2014 were randomly collected and evaluated. Patients were treated with different types and doses of diuretics, vasodilators, aldehyde steroids, or angiotensin II receptor antagonists, based on individual patient data. The numbers of patients with marked response, response, and no response after treatment were evaluated. Inpatient costs at weeks 1, 2, 3, and 4 of treatment were recorded and the mean cost per inpatient day were calculated. Heart rate, systolic pressure, diastolic pressure, left ventricular ejection fraction （LVEF）, and left ventricular end-diastolic dimension （LVDd） were evaluated before and after treatment. Results After treatment, the numbers of patients with marked response, response, and no response were 35, 14, and 1, respectively, which resulted in an overall response rate of 98%. The heart rate, systolic pressure, diastolic pressure, LVEF, and LVDd were significantly improved after treatment （P〈0.05）. The inpatient cost was the highest at the first week of treatment and significantly decreased along with recovery of patients （P〈0.05）. The mean cost per inpatient day showed a significant time-dependent decrease during the course of treatment （P〈0.05）. Conclusion Patients with severe chronic heart failure should be treated with personalized medication to achieve the best clinieal outcomes with the lowest inpatient cost.
出处
《心血管病防治知识（学术版）》
2014年第12期75-77,共3页
Prevention and Treatment of Cardiovascular Disease
关键词
重症
慢性心力衰竭
个体化
药物治疗
Severe
Chronic heart failure
Personalized
Medication
