摘要
目的:探讨普伐他汀对慢性心力衰竭(CHF)患者血浆脑钠素(BNP)水平和心功能的影响。方法:将56例CHF患者随机分为普伐他汀组(30例)和对照组(26例),2组均给予常规治疗,普伐他汀组另加普伐他汀10mg,qn,疗程8周。测定治疗前、后左心室舒张末内径(LVDd)、左心室射血分数(LVEF)、血浆BNP浓度的变化。结果:普伐他汀治疗8周后,血浆BNP浓度由(218.6±64.2)ng/L降至(149.4±50.1)ng/L(P<0.01);LVEF由(34.4±3.4)%升至(45.4±4.9)%(P<0.05),LVDd由(65.5±5.1)mm降至(45.4±4.9)mm(P<0.05),与对照组比较均差异有统计学意义;且患者血浆BNP降低值与LVEF增加存在负相关(r=-0.71,P<0.01),而与LVDd减少呈正相关(r=0.79,P<0.05)。结论:普伐他汀能明显改善心功能,抑制血浆BNP增高。
Objective：To investigate the change of cardiac function and plasma brain natriuretic peptide （BNP） levels in patients with chronic heart failure（CHF） after pravastatin treatment. Method：Fifty-six patients with CHF were randomly divided into two groups, pravastatin group （30 patients） and control group （26 patients）. Patients in the pravastatin group were given pravastatin 10 mg/d for 8 weeks besides conventional therapy. Plasma BNP, and echocardiographic indices were evaluated before and after 8 weeks＇ therapy. Result： Pravastatin significantly decreased LV diastolic dimensions and increased LV ejection fraction （P〈0. 05） as well as attenuated BNP （P〈0.01） in patients in pravastatin group, compared with in control group. Meanwhile, the change of BNP level was positively correlated with LVDd （r=0.79） （P〈0.01） , and negatively correlated with LVEF （r= - 0.71） （P〈0.01）. Conclusion：Pravastatin may improve cardiac function and suppress plasma BNP in patients with CHF.
出处
《临床心血管病杂志》
CAS
CSCD
北大核心
2007年第8期588-589,共2页
Journal of Clinical Cardiology
关键词
心力衰竭
充血性
脑钠素
心室功能
左
普伐他汀
Heart failure ,congestive
Brain natriuretic peptide
Ventricular function, left
Pravastatin
