期刊文献+

13种蓝花荆芥提取物体外抗单纯疱疹病毒1型活性研究 被引量:9

Study on the anti-HSV-1 activity of 13 extracts from Nepeta coerulescens Maxim in vitro
原文传递
导出
摘要 目的从13种蓝花荆芥提取物中筛选具有体外抗单纯疱疹病毒1型活性的成分。方法采用细胞病变效应法(Cytopathogenic effect,CPE)测定不同蓝花荆芥提取物的药物毒性及抗单纯疱疹病毒1型的活性。结果从13种蓝花荆芥提取物中筛选到了7种具有抗单纯疱疹病毒1型活性的成分。结论筛选得到的7种蓝花荆芥提取物具有抗HSV-1的活性,适用于抗单纯疱疹病毒1型治疗药物的深入研究与开发。 Objective To investigate the anti- herpes simplex virus typel (HSV- 1 ) activities of 13 extracts from Nepeta coer- ulescens Maxim in vitro. Methods Cytotoxicity and anti - herpes simplex virus type1 activity of different extracts were determined by cytopathogenic effect assay (CPE). Results Seven active extracts from Nepeta coerulescens Maxim showed antiviral activities toward HS~ - 1. Conclusion Some extracts from Nepeta coerulescens Maxim have anti - HSV - 1 activity in vitro and can be used for the further research and development of anti - HSV - 1 drugs.
出处 《时珍国医国药》 CAS CSCD 北大核心 2014年第12期3054-3055,共2页 Lishizhen Medicine and Materia Medica Research
基金 国家自然科学基金(No.81160554) 国家自然科学基金(No.81274170) 国家自然科学基金与广东省人民政府自然科学联合基金(No.U0632010) "十二五"国家科技支撑计划(No.2012BAI29B06) 广东省教育厅高等学校高层次人才项目资金([2010]NO.79)
关键词 蓝花荆芥 单纯疱疹病毒1型 抗病毒 细胞病变效应法 Nepeta coerulescens Maxim Herpes simplex virus type 1 Antiviral activity Cytopathogenic effect
  • 相关文献

参考文献5

二级参考文献12

  • 1何耀松,张继东.桉树化学成分及药理作用研究进展[J].动物医学进展,2007,28(7):98-101. 被引量:25
  • 2李家泰.临床药理学[M].北京:人民卫生出版社,1998.741-742. 被引量:74
  • 3Faulds NS. Ganciclovir:an update of its use in the prevention of cytomegalocirus infection and disease in transplant recipients[J].Drugs ,1998,56 (1) : 115 - 146. 被引量:1
  • 4Jabs DA, Griffiths PD. Fomivirsen for the treatment of cytomegalovirus retinitis [J ]. Am J Ophthalmol, 2002, 133 (4) :552 - 556. 被引量:1
  • 5Curran M, Noble S. Valganciclovir [ J ]. Drugs, 2001,61 (8) :1145- 1150. 被引量:1
  • 6Naesens L, De Clercq E. Recent developments in herpes virus therapy[ J ]. Herpes, 2001,8( 1 ) : 12 - 16. 被引量:1
  • 7Gnann JW JR, Crumpacker CS, Lalezari JP, et al. Sorivudine versus acyclovir for treatment of dermatomal herpes zoster in human immunodeficiency virus-infected patients: Results from a randomized, controlled clinical trial[ J ]. Antimicro Agents Chemother, 1998,42 ( 5 ) :1139- 1145. 被引量:1
  • 8Perry CM,Faulds D. Valaciclovir:a review of its antiviral activity, pharmacokinetic properties and therapeutic efficacy in herpesvirus infections[J]. Drugs, 1996,52(5) :754 - 772. 被引量:1
  • 9Perry CM, Wagstaff AJ. Famciclovir: a review of its pharmacological properties and therapeutic efficacy in herpes virus infections[ J]. Drugs, 1995,50 (2) : 396 - 415. 被引量:1
  • 10Lea AP, Bryson HM. Cidofovir [ J ]. Drugs, 1996, 52 (2) :225 - 230. 被引量:1

共引文献49

同被引文献246

引证文献9

二级引证文献128

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部