摘要
目的:评价头孢替安钠与呋塞米合用的安全性,为临床用药提供参考。方法:设空白组、头孢替安钠500 mg·kg-1·d-1组、头孢替安钠500 mg·kg-1·d-1+呋塞米15 mg·kg-1·d-1组,给药12d后检测大鼠肾脏结构,以及血清尿酸、肌酐、尿素氮,大鼠尿α1微球蛋白,β2微球蛋白等水平。结果:头孢替安钠500 mg·kg-1·d-1给药后对大鼠的肾脏结构,血清尿酸、肌酐、尿素氮,大鼠尿α1微球蛋白、β2微球蛋白无明显影响,头孢替安钠500 mg·kg-1·d-1+呋塞米15 mg·kg-1·d-1给药后引起大鼠尿β2微球蛋白显著上升(P<0.05),血清尿酸显著下降(P<0.05)。结论:短期使用头孢替安钠对大鼠的肾功能及肾脏结构无明显影响,而头孢替安钠+呋塞米对大鼠尿β2微球蛋白及血清尿酸有一定影响。
Objective : To evaluate the safety of the combination of cefotiam sodium and furosemide and to provide the reference for clinical medication. Methods: Three groups were established, including the blank control group, cefotiam sodium group at the dosage of 500 mg- kg-1 1 d-1 , cefotiam sodium combined with furosemide group at the respective dosage of 500 mg 1 kg-1 - d-1 and 15 mg 1 kg-1 1 d-l. After the continuous administration for 12 days, the renal structure, serum uric acid, creatinine and urea nitrogen, u- rine of al microglobulin and β2 microglobulin in the rats were detected. Results: Cefotiam sodium at the dosage of 500 kg -1 . d- 1 showed no significant effects on the renal structure, serum uric acid, creatinine and urea nitrogen ,urine a1 microglobulin and β2 microglobulin in the rats. The combination- group showed significantly increased urine β2 microglobulin ( P 〈 0.05 ) and significantly decreased serum uric acid ( P ,〈 0.05 ). Conclusion : Short time use of cefotiam sodium exhibits no significant effect on the renal struc- ture and function in rats, while the combination of cefotiam sodium and furosemide has significant effects on urine β2 microglobulin and serum uric acid in rats.
出处
《中国药师》
CAS
2015年第1期161-163,共3页
China Pharmacist
关键词
头孢替安钠
呋塞米
合用
安全性
Cefotiam sodium
Furosemide
Combination use
Safety