摘要
赖氨酸特异性组蛋白去甲基化酶（LSDl）是一个黄素腺嘌呤二核苷酸（FAD）依赖性单胺氧化酶，它能够特异性脱去单甲基化和二甲基化H3K4和H3K9位点上的甲基基团，从而调节基因的转录活性。LSDl对哺乳动物的发育至关重要，并参与许多生物学过程，包括细胞类型的分化、基因活化和基因抑制。目前证实LSDl可促进细胞相变（缺乏LSDl导致部分细胞周期阻滞在G2／M期）和细胞增殖。提示其过表达可促进肿瘤的发生。LSDl作为一种去甲基化酶，有可能成为一个新的抗肿瘤治疗靶点。现对LSDl的结构、作用方式以及其与肿瘤发生的关系等方面进行综述。
Lysine specific demethylase 1 （ LSD1 ） is a kind of flavin adenine dinucleotid（FAD） dependent amine oxidase and can specifically demethylate H3K4me2/mel and H3K9me2/mel, thus it can regulate gene transcriptional activity. LSD1 is essential for mammalian development and is involved in many biological proces- ses,including cell differentiation, gene activation, and gene repression. Nowadays, it is demonstrated that LSD1 might promote cell phase transition（ deficiency in LSD1 leads to partial cell cycle arrest in G2/M） and cell prolif- eration, suggesting that the over- expression of LSD1 might promote tumorigenesis. LSD1, as a demethylase, may be a new target for anti -cancer therapy. Hereby, we review on the structure, action mode of LSD1 and its rela- tionshit） with oncogenesis.
出处
《实用肿瘤学杂志》
CAS
2014年第6期569-572,共4页
Practical Oncology Journal
