摘要
目的探讨原发性高血压(EH)患者N末端脑钠肽前体(NT-pro BNP)及淋巴细胞亚群等指标变化情况。方法 328例高血压确诊患者按照分级标准进行分组,其中EH1级组115例,EH2级组109例,EH3级组104例;以120例同期健康体检者作为对照组。采用电化学发光免疫分析测定NT-pro BNP水平和流式细胞仪分析CD3+、CD4+、CD8+、CD19+水平,组间进行比较。结果高血压组血清中NT-pro BNP、CD4+/CD8+、CD19+水平较健康对照组明显升高(P<0.05),其中EH3级组升高最显著;CD3+、CD4+、CD8+细胞明显低于正常对照组(P<0.05),EH3级组降低最显著。NT-pro BNP水平与CD3+、CD4+、CD8+等指标均呈显著负相关(r=-0.951,r=-0.973,r=-0.955;P均<0.01),与CD19+细胞(B细胞)、CD4+/CD8+呈显著正相关(r=0.934,r=0.98;P均<0.01)。结论 EH患者的血压的临床分级与NT-pro BNP、CD3+、CD4+、CD8+、CD19+的水平密切相关,并可能参与EH的病理生理过程。
Objective To study the change of N-terminal pro-brain natriuretic peptide and lymphocyte subpopulation in essential hypertensive patients. Methods Totally 328 hypertensive patients were divided into three groups according to the standard of classification： grade 1 hypertensive（115 patients）, grade 2 hypertensive（109 patients） and grade 3 hypertensive（104 patients）. As the same time 120 normal controls were enrolled as control group.CD3^＋、CD4^＋、CD8^＋、CD19^＋level and serum NT-pro BNP concentration were measured by flow cytometry and electrochemiluminescence immunoassay（ECLIA）. Results NT-pto BNP, CD4/CD8 and CD19^＋levels in 328 patients with EH were significantly higher than those in the controls（P〈0.05） and they were increased with the increases of blood pressure, but CD3^＋, CD4^＋and CD8^＋levels were significantly lower（P〈0.05） than the control and they were decreased with the increases of blood pressure. NT-pro BNP level was negatively correlated with CD3^＋, CD4^＋and CD8^＋（r=-0.951,r=-0.973, r=-0.955; P〈0.01）, and was positively correlated with CD19^＋and CD4^＋/CD8^＋（r=0.934, r=0.98; P〈0.01）.Conclusion NT-pro BNP, CD3^＋, CD4^＋, CD8^＋and CD19^＋were closely correlated with EH stage and probably involved in the pathophysiological process of EH.
出处
《海南医学》
CAS
2014年第23期3486-3488,共3页
Hainan Medical Journal
关键词
原发性高血压
N末端脑钠肽前体
淋巴细胞亚群
Essential hypertension
N-terminal pro-brain natriuretic peptide（NT-pro BNP）
Lymphocyte subpopulation
