摘要
目的:探讨老年高血压(EH)合并颈动脉硬化(CAS)患者血管紧张素Ⅱ(AngⅡ)水平与中医证型的相关性。方法:对123例老年EH合并CAS患者测定血管紧张素Ⅱ水平,结合四诊进行中医辨证分型,对相关数据进行统计分析。结果:(1)不同中医证型间AngⅡ水平(pg/mL)的比较:痰湿壅盛(72.90±16.74)pg/mL>阴阳两虚(66.69±12.85)pg/mL>阴虚阳亢(61.99±8.67)pg/mL>肝火亢盛(55.93±8.52)pg/mL,P<0.05;(2)高血压分级间AngII水平(pg/mL)的比较:EH1级(53.98±7.02)pg/mL<EH2级(64.42±5.27)pg/mL<EH3级(74.11±17.1)pg/mL,P<0.01;(3)高血压危险分层间AngII水平(pg/mL)的比较:低危组(49.0±0.63)pg/mL<中危组(56.38±8.25)pg/mL<高危组(67.91±11.02)pg/mL<极高危组(68.03±14.47)pg/mL,P<0.01。结论:老年EH合并CAS患者AngII水平与痰湿壅盛型、阴阳两虚型关系密切;与高血压分级、高血压危险分层存在相关性。
Objective：To study the correlation of the angiotensin II （ AngII ）level with the TCM syndromes in patients over 60 years old with essential hypertension （EH）and carotid atherosclerosis （CAS）disease. Methods ：123 cases of elderly EH patients with CAS by plasma angiotensin II was detected by radioimmunoassay kit,TCM syndrome was differentiated by the four diagnos- tics. And then we analyzed the data. Results ： （ 1 ） The AngII levels in different TCM syndromes of type ： phlegm dampness type （72. 90 -＋ 16. 74 ） pg/mL 〉 yin - yang deficiency type （66. 69 -＋ 12. 85 ） pg/mL 〉 hyperactivity of Yang due to yin deficiency （61.99 ＋ 8.67）pg/mL 〉 liver-fire excess type （55.93 ＋ 8. 52）pg/mL in which the phlegm dampness type and the other three groups had significant difference（ P 〈 O. 05 ）. （2）AngII level （pg/mL）comparison in hypertension grading： EH1 （53.98 ＋ 7.02 ） pg/mL 〈 EH2 （ 64.42 _＋ 5.27 ） pg/mL 〈 EH3 （ 74. 11 _＋ 17. 1 ） pg/mL, with significant difference （ H = 80.321, P 〈 0. 01 ）. （ 3 ） An- glI level（pg/mL） comparison in hypertension risk stratification：the low risk group（49.0 -＋ 0. 63 ）pg/mL 〈 risk group （56.38 ＋ 8.25 ）pg/mL 〈 high risk group（ 67.91 -＋ 11.02 ）pg/mL 〈 very high risk group（ 68.03 -＋ 14.47 ）pg/mL, with significant difference （ H = 25.816,P 〈 0. 01 ）. Conclusion：The serum level of AnglI has significant correlation with TCM yin-yang deficiency type and syndrome phlegm-dampness type, and the serum level of AnglI has significant correlation with grade of hypertension and hyperten- sive risk stratification.
出处
《辽宁中医杂志》
CAS
2013年第5期912-914,共3页
Liaoning Journal of Traditional Chinese Medicine
