摘要
目的探讨CYP11B2(C-344T)基因多态性与原发性高血压(EH)危险分层的相关性。方法根据《中国高血压防治指南》中高血压危险分层方法,将244例EH患者分为中危组、高危组和极高危组,采用多聚酶链式反应-限制性片断长度多态性(PCR-RFLP)法检测CYP11B2(C-344T)基因多态性,相关分析采用χ2检验。结果EH组、EH危险分层各组及对照组基因型频率和等位基因频率均符合Hardy-Weinberg平衡定律。EH组CC、TT基因型频率高于对照组,TC基因型频率低于对照组,但差异无统计学意义(P>0.05)。EH组T和C等位基因频率与对照组相近(P>0.05);中危组、高危组、极高危组及对照组之间两两比较,TT、TC、CC基因型频率及T、C等位基因频率差异无统计学意义(P>0.05)。结论CYP11B2(C-344T)基因多态性与高血压危险分层无相关性。
Objective To investigate the correlation between the polymorphisms of CYP11B2 （C-344T） and essential hypertensive risk stratification. Methods According to Chinese guideline for prevention and treatment of hypertension,244 cases with essential hypertension were divided into medium risk group, high risk group and very high risk group. Polymorphisms of CYPllB2（C-344T） gene were detected by PCR-restriction fragment length polymorphisms. The possible association was tested by Х^2 test. Results The frequency of genotype and allele of CYP11B2 （C-344T） in all groups were consistent with Hardy- Weinberg equilibrium. The frequency of CC and TT genotype in essential hypertension（EH） group was higher than that in control group,the frequency of TC genotype was lower than that in control group, but the differences were no statistically significant （P 〉 0.05 ）. T and C allele frequency in EH group was similar with that in control group（ P 〉 0.05 ）. There was no statistically significant in the frequency of TT,TC, CC ,T allele and C allele among medium risk group, high risk group, very high risk group and control group （ P 〉 0. 05 ）. Conclusion The polymorphisms of CYP11B2 （C-344T） gene are unrelated with essential hypertensive risk stratification.
出处
《新乡医学院学报》
CAS
2009年第6期553-556,共4页
Journal of Xinxiang Medical University
基金
新乡医学院科学研究项目(编号:2005YJ31)
