摘要
胆碱能抗炎通路(CAP)是近年发现的在神经免疫网络中发挥炎症调节作用的重要抗炎通路。α7烟碱型乙酰胆碱受体(α7 nAChR)是目前较明确的在CAP中发挥关键作用的受体,在免疫细胞上表达的α7 nAChR参与细胞增殖活化及炎症反应的调节,α7 nAChR已成为炎症相关性疾病的药物治疗靶标。本文综述CAP中α7 nAChR的作用机制及对免疫细胞的调节作用,并阐述中医药通过CAP发挥抗炎作用的研究现状。
Nicotinic acetylcholine receptor alpha7（α7 n ACh R）is a receptor which participates in the activation of cell proliferation and the regulation of inflammatory response. It is confirmed that α7 n ACh R plays an important role in the cholinergic anti-inflammatory pathway（CAP）,and has become the therapeutic target of inflammation-related diseases.This paper reviews the mechanism of α7 n ACh R in CAP and the regulatory effect ofα7 n ACh R on immune cells,and clarified that CAP may be one of the anti-inflammatory pathway of traditional Chinese medicine.
出处
《中药新药与临床药理》
CAS
CSCD
北大核心
2014年第6期760-765,共6页
Traditional Chinese Drug Research and Clinical Pharmacology
关键词
胆碱能抗炎通路
α7
NACHR
免疫细胞
中医药
Cholinergic anti-inflammatory pathway
Nicotinic acetylcholine receptor alpha7（α7 nAChR）
Immune cells
Traditional Chinese Medicine
