摘要
目的:观察卫分证与气分证、营分证白细胞介素-6(IL-6)、白细胞介素-10(IL-10)变化规律,为卫气营血辨证提供客观的实验指标。方法:将104例患者按不同病种分为急性白血病、非急性白血病2 类。根据中医辨证急性白血病分为卫分证组(白卫组)10例,气分证组(白气组)12例,营分证组(白营组)20 例。非急性白血病分为卫分证组(非白卫组)20例,气分证组(非白气组)24例,营分证组(非白营组)18例。另选择体检健康者15例为健康对照组。主要观察不同病种及不同阶段卫分证、气分证、营分证患者IL-6、IL-10 水平的变化。结果:急性白血病各组中IL-6的表达在卫分证时就开始上升,到营分证时达到极点,与健康对照组比较,差异均有非常显著性意义(P<0.01);IL-10在气分证才开始上升,与健康对照组比较,差异有非常显著性意义(P<0.01),但到营分证时又显著下降,甚至低于健康对照组(P<0.01)。非急性白血病各组中IL-6的表达在卫分证时开始上升,到营分证时也达到高峰,与健康对照组比较,差异均有非常显著性意义(P <0.01);IL-10也在气分证才开始上升,与健康对照组比较,差异有非常显著性意义(P<0.01),到营分证时又显著下降,但与健康对照组比较,差异无显著性意义(P>0.05)。急性白血病各组与非急性白血病各组比较:IL-6。
Objective: To observe the regular pattern changes of IL - 6 and IL - 10 in weifen syndrome (WS), qifen syndrome (QS) and yingfen syndrome (YS) and to provide objective parameters for the syndrome differentiation of Wei, Qi, Ying and Xue. Methods: 104 cases of different diseases were classified to a-cute leukemia (AL) and non - acute leukemia (NAL) groups. According to syndrome differentiation of TCM, the AL group was classified to WS (10 cases), QS (12 cases)and YS (20 cases). The NAL group was classified to WS (20 cases), QS (24 cases) and YS (18 cases), and 15 health cases served as control group (CG) . The levels of IL - 6 and IL-10 were observed in various diseases and syndromes. Results: In AL group, the level of IL - 6 began to increase in WS and attained the peak in YS, compared with CG ( P < 0. 01). The level of IL - 10 began to increase in QS in P < 0. 01 as compared with CG and markedly decreased in YS but P > 0. 05 as compared with CG. The comparison between AL group and NAL group showed that the IL-10 also began increase, the levels of IL -6 and IL-10 in WS showed no significant difference (P > 0. 05) but significant differences in QS and YS (P < 0.01), but the tendency of increase or decrease of IL - 6 and IL -10 were identical to the changes of syndrome. Conclusion: IL - 6 is one of the parameters showing the healthy qi counteracting pathogenic factor in Wei, Qi, Ying and Xue syndrome of seasonal febrile disease, while IL-10 reflected one of the parameters of inclination or declination of bodily healthy qi. Therefore, the dynamic change of IL - 6 and IL - 10 is one of the objective parameters for differentiation of WS, QS and YS.
出处
《新中医》
CAS
北大核心
2005年第6期19-21,共3页
New Chinese Medicine
基金
湖南省自然科学基金资助项目(编号:OOJJY2034)
关键词
卫气营血辨证
微观辨证
辨证规范化
白细胞介素6
白细胞介素10
syndrome differentiation of Wei, Qi, Ying and Xue
syndrome differentiation, microcosmic
standardization of syndrome differentiation
interleukin - 6
interleukin - 10
